Author

E. Law

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Microbiology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

R. Harris· 5 shared M. Carpenter· 3 shared P. Argyris· 3 shared G. Starrett· 2 shared J. McCann· 2 shared L. Larson· 2 shared M. Jarvis· 2 shared R. Levin-Klein· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersCancer Biology

R. Harris

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Applying And Promoting Open Science In Ecology - Surveyed Drivers And Challenges

C. B. Stromme, A. K. Lane, A. H. Halbritter, E. Law, C. R. Nater, E. B. Nilsen, G. D. Boutouli, D. D. Egelkraut, R. J. Telford, V. Vandvik, S. H. Cotner

This study surveys OS practitioners in ecology to identify drivers and challenges of open science engagement, finding that formal education and institutional support are critical for adoption.

bioRxiv · Oct 12, 2021 · PreprintScientific Communication & Education

R-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B

J. McCann, A. Cristini, E. Law, S. LEE, M. Tellier, M. Carpenter, C. Beghe, J. Kim, M. C. Jarvis, B. Stefanovska, N. A. Temiz, E. N. Bergstrom, D. Salamango, M. Brown, S. Murphy, , R. Harris

This study shows APOBEC3B regulates R-loop homeostasis and contributes to mutagenesis in cancer by binding R-loops and altering their landscape.

bioRxiv · Aug 30, 2021 · PreprintCancer Biology

An immunogenic model of KRAS-mutant lung cancer for study of targeted therapy and immunotherapy combinations

J. Boumelha, S. de Carne Trecesson, E. Law, P. Romero-Clavijo, M. Coelho, K. Ng, E. Mugarza, C. Moore, S. Rana, D. Caswell, M. Murillo, D. Hancock, P. Argyris, W. Brown, C. Durfee, , J. Downward

This paper develops an immunogenic mouse model of KRAS-mutant lung cancer that responds to immunotherapy and reveals immune responses target endogenous retroviral antigens rather than neoantigens.

bioRxiv · Dec 22, 2020Cancer Biology

APOBEC3A Catalyzes Mutation and Drives Carcinogenesis In Vivo

E. Law, R. Levin-Klein, M. Jarvis, H. Kim, P. Argyris, M. Carpenter, G. Starrett, L. Larson, M. Burns, R. Vogel, S. Stavrou, A. Aguilera, S. Wagner, D. Largaespada, T. Starr, , R. Harris

This study shows APOBEC3A promotes tumorigenesis in mice and supports its role in causing mutations in human cancers.

bioRxiv · Dec 27, 2019Cancer Biology

A rabbit monoclonal antibody against the antiviral and cancer genomic DNA mutating enzyme APOBEC3B

W. Brown, E. Law, M. Carpenter, P. Argyris, R. Levin-Klein, A. Ranum, A. Molan, C. Forster, B. Anderson, L. Lackey, R. Harris

This paper describes the generation and characterization of a rabbit monoclonal antibody against APOBEC3B, showing its potential as a research tool and clinical biomarker for cancer.

bioRxiv · Jan 7, 2019Cancer Biology

Polyomavirus T-Antigen Induces APOBEC3B Expression using a LXCXE-Dependent and TP53-Independent Mechanism

G. Starrett, A. Serebrenik, P. Roelofs, B. Verhalen, J. McCann, M. Jarvis, T. Stewart, E. Law, A. Krupp, M. Jiang, J. Martens, P. Span, E. Cahir-McFarland, R. Harris

This paper shows polyomavirus T-antigen induces APOBEC3B expression via the LXCXE motif without requiring TP53 inhibition, linking RB/E2F axis activation to APOBEC3B upregulation in virus-infected cells.

bioRxiv · May 2, 2018Microbiology