Author

M. Carpenter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

R. Harris· 5 shared E. Law· 3 shared D. Salamango· 2 shared J. Wang· 2 shared K. Shi· 2 shared N. Shaban· 2 shared P. Argyris· 2 shared R. Levin-Klein· 2 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersCancer Biology

R. Harris

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Modeling cellular co-infection and reassortment of bluetongue virus in Culicoides midges

S. M. Cavany, C. Barbera, M. Carpenter, C. Rodgers, M. D. M. Stenglein, C. Mayo, A. Perkins

The paper develops mathematical models to study bluetongue virus reassortment in Culicoides midges, finding that small fitness differences between strains significantly affect reassortant frequency.

bioRxiv · Jun 3, 2022Microbiology

Single immunization with recombinant ACAM2000 vaccinia viruses expressing the spike and the nucleocapsid proteins protect hamsters against SARS-CoV-2 caused clinical disease

J. Cao, Y. Deschambault, J. Lynch, B. Warner, K. Tierney, D. Huynh, R. Vendramelli, N. Tailor, S. Booth, B. Sajesh, K. Frost, K. LeBlanc, C. Layne, L. Lin, D. Beniac, , D. Kobasa

This study shows that a single immunization with a vaccinia virus expressing both SARS-CoV-2 spike and nucleocapsid proteins protects hamsters better than expressing either protein alone.

bioRxiv · Dec 2, 2021Microbiology

CryoEM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition

N. Shaban, R. Yan, K. Shi, S. Moraes, A. Cheng, M. Carpenter, J. S. McLellan, Y. Zhiheng, R. Harris

This study reveals how EBV's BORF2 protein inhibits APOBEC3B by blocking its access to DNA, providing insights for drug development.

bioRxiv · Aug 30, 2021 · PreprintMicrobiology

R-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B

J. McCann, A. Cristini, E. Law, S. LEE, M. Tellier, M. Carpenter, C. Beghe, J. Kim, M. C. Jarvis, B. Stefanovska, N. A. Temiz, E. N. Bergstrom, D. Salamango, M. Brown, S. Murphy, , R. Harris

This study shows APOBEC3B regulates R-loop homeostasis and contributes to mutagenesis in cancer by binding R-loops and altering their landscape.

bioRxiv · Aug 30, 2021 · PreprintCancer Biology

APOBEC3A Catalyzes Mutation and Drives Carcinogenesis In Vivo

E. Law, R. Levin-Klein, M. Jarvis, H. Kim, P. Argyris, M. Carpenter, G. Starrett, L. Larson, M. Burns, R. Vogel, S. Stavrou, A. Aguilera, S. Wagner, D. Largaespada, T. Starr, , R. Harris

This study shows APOBEC3A promotes tumorigenesis in mice and supports its role in causing mutations in human cancers.

bioRxiv · Dec 27, 2019Cancer Biology

HER2 Cancer Protrusion Growth Signaling Regulated by Unhindered, Localized Filopodial Dynamics

W. Y. Lam, Y. Wang, B. Mostofian, D. Jorgens, S. Kwon, K. Chin, M. Carpenter, T. Jacob, K. Heiser, A. Agrawal, J. Wang, X. Nan, Y. H. Chang, D. M. Zuckerman, J. Gray, , T. Q. Vu

This study investigates how HER2 dynamics in filopodia regulate protrusion growth and signaling in breast cancer cells, revealing distinct motion patterns and functional roles in protrusion-based signaling.

bioRxiv · Jun 2, 2019 · PreprintCancer Biology

A rabbit monoclonal antibody against the antiviral and cancer genomic DNA mutating enzyme APOBEC3B

W. Brown, E. Law, M. Carpenter, P. Argyris, R. Levin-Klein, A. Ranum, A. Molan, C. Forster, B. Anderson, L. Lackey, R. Harris

This paper describes the generation and characterization of a rabbit monoclonal antibody against APOBEC3B, showing its potential as a research tool and clinical biomarker for cancer.

bioRxiv · Jan 7, 2019Cancer Biology

The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by a RNA-Mediated Dimerization Mechanism

R. Harris, N. Shaban, K. Shi, K. Lauer, M. Carpenter, C. Richards, M. Lopresti, D. Salamango, J. Wang, S. Banerjee, W. Brown, H. Aihara

This study identifies an RNA-mediated dimerization mechanism that regulates APOBEC3H DNA deaminase activity, localization, and antiviral function.

bioRxiv · Oct 13, 2017Microbiology