Author

D. Shaffer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:perturbation response prediction· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

L. Wang· 2 shared X. Li· 2 shared A. Choi· 1 shared B. Liu· 1 shared C. C. Le· 1 shared C. Okwuchi· 1 shared C. Shi· 1 shared D. Bangari· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersImmunology

L. Wang

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

CD8 T-cell dysfunction is linked with CAR T-cell failure and can be mitigated by a non-alpha IL-2 agonist, pegenzileukin

P. K. Reville, I. N. Sheikh, A. Choi, E. Dai, J. Henderson, X. Li, E. Rojas, C. C. Le, C. Okwuchi, M. Devonish, R. Carrio, N. Pate, K. Malley, D. Bangari, J.-A. Givigan, , M. R. Green

The paper identifies dysfunctional CD8 CAR T-cells in rrLBCL tumors and shows that pegenzileukin mitigates this dysfunction, improving CAR T-cell responses.

bioRxiv · Aug 28, 2023 · PreprintImmunology

Unleashing the Power of NR4A1 Degradation as a Novel Strategy for Cancer Immunotherapy

L. Wang, Y. Xiao, Y. Luo, R. P. Master, J. Mo, M.-C. Kim, Y. Liu, U. M. Patel, X. Li, D. Shaffer, K. R. Guertin, E. Moser, K. Smalley, D. Zhou, G. Zheng, W. Zhang

This paper develops a PROTAC molecule (NR-V04) that degrades NR4A1, leading to tumor inhibition and immune modulation in melanoma.

bioRxiv · Aug 9, 2023 · PreprintCancer Biology