E. Rojas

CREBBP lysine acetyltransferase domain mutations create zombie enzymes that alter chromatin loading dynamics and prevent EP300 redundancy

The paper shows that CREBBP mutations disrupt chromatin loading dynamics and EP300 redundancy, creating zombie enzymes that impair enhancer activation in GC B-cells and lymphoma.

CD8 T-cell dysfunction is linked with CAR T-cell failure and can be mitigated by a non-alpha IL-2 agonist, pegenzileukin

The paper identifies dysfunctional CD8 CAR T-cells in rrLBCL tumors and shows that pegenzileukin mitigates this dysfunction, improving CAR T-cell responses.

No evidence for an effect of chronic boat noise on the fitness of reared water fleas

This study reared Daphnia magna in the presence or absence of motorboat noise and found no effect on their lifespan or reproductive output.

Chronic broadband noise increases the fitness of a laboratory-raised freshwater zooplankton

This study shows chronic broadband noise increases fitness in Daphnia magna by enhancing survival and fecundity, though it reduces mobility.

From behaviour to complex communities: Resilience to anthropogenic noise in a fish-induced trophic cascade

The paper investigates how chronic motorboat noise affects a freshwater trophic cascade, finding that roach predation on plankton remains stable despite altered feeding behavior.

Feedback linking cell envelope stiffness, curvature, and synthesis enables robust rod-shaped bacterial growth

This study combines theory and experiment to show that E. coli uses feedback between cell-envelope curvature and expansion to maintain growth rate and cell width during osmotic stress.

Bacterial evolution in high osmolarity environments

This study evolves Escherichia coli in high osmolarity environments and finds that adaptation strategies vary by osmolyte, with specific mutations improving fitness in certain conditions.

A mechanical cusp catastrophe imposes a universal developmental constraint on the shapes of tip-growing cells

The paper identifies a mechanical constraint on tip-growing cell shapes using a cusp catastrophe model, showing natural shapes are bounded by a bifurcation in morphospace.