G. Zheng

This paper develops a PROTAC molecule (NR-V04) that degrades NR4A1, leading to tumor inhibition and immune modulation in melanoma.

This paper demonstrates that an engineered nanobody-E3 ubiquitin ligase adapter fusion can effectively degrade tau in mouse neurons by leveraging nuclear proteasomal activity.

A cell-permeant nanobody-based degrader depletes BCL11A in erythroid cells, inducing fetal hemoglobin expression.

The paper develops a microfluidic chip for LAMP-based multiplex detection of three bacterial pathogens and reports LOD values for Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.

This paper develops a microfluidic chemostatic bioreactor for high-throughput screening of microalgal growth and lipid production, achieving higher throughput and efficiency compared to traditional methods.

The paper develops a microfluidic droplet array for high-throughput screening of lipid-producing microalgae, enabling real-time monitoring and identification of individual cells under different conditions.

This paper introduces VENAS, a system for analyzing SARS-CoV-2 genome evolution networks, enabling rapid processing and visualization of large datasets to trace viral mutations and transmission.

The paper identifies piperlongumine as a covalent E3 ligase recruiter that, when conjugated with CDK9 inhibitors, induces targeted protein degradation of CDK9 and EML4-ALK fusion oncoprotein.

The paper develops a cost-effective microscopy system for high-throughput optical recordings of visceral afferent activity in mouse dorsal root ganglia.

This study shows that deletion of RgsA in Pseudomonas aeruginosa reduces growth and oxidative stress resistance in both planktonic and biofilm states.

This study shows that mantle tissue retraction and dislocation in Pinctada fucata directly control shell regeneration by accelerating CaCO3 nucleation through increased shell matrix protein expression.