Author

E. C. Freckmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:imaging· 1

Frequent Co-Authors

A. Roman-Fernandez· 3 shared E. Sandilands· 3 shared L. McGarry· 3 shared D. M. Bryant· 2 shared D. Strachan· 2 shared E. M. Cumming· 2 shared H. Y. Leung· 2 shared J. Anand· 2 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

A. Roman-Fernandez

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Author profile →

3 papers

Recent·Most cited

PTEN deficiency exposes a requirement for an ARF GTPase module in integrin-dependent invasion in ovarian cancer.

K. Nikolatou, E. Sandilands, A. Roman-Fernandez, E. M. Cumming, E. C. Freckmann, S. Lilla, L. Buetow, L. McGarry, M. Neilson, R. Shaw, D. Strachan, C. Miller, D. T. Huang, I. A. McNeish, J. C. Norman, , D. Bryant

This study identifies ARF6 as a critical vulnerability in PTEN-deficient ovarian cancer, showing its role in integrin-dependent invasion and its inverse association with patient outcomes.

bioRxiv · Nov 29, 2022Cancer Biology

Spatial regulation of the glycocalyx component Podocalyxin is a switch for pro-metastatic function

A. Roman-Fernandez, M. Mansour, F. G. Kugeratski, J. Anand, E. Sandilands, L. Galbraith, K. Rakovic, E. C. Freckmann, E. M. Cumming, J. Park, K. Nikolatou, S. Lilla, R. Shaw, D. Strachan, S. Mason, , D. M. Bryant

This study identifies PODXL as a decoy receptor for GAL3, revealing its role in promoting metastasis through integrin-based invasion and differential cortical targeting regulated by ubiquitination.

bioRxiv · Nov 4, 2022 · PreprintCell Biology

The small GTPase ARF3 controls metastasis and invasion modality by regulating N-cadherin levels.

E. Sandilands, E. C. Freckmann, A. Roman-Fernandez, L. McGarry, L. Galbraith, S. Mason, R. Patel, J. Anand, J. Cartwright, H. Y. Leung, K. Blyth, D. M. Bryant

This study identifies ARF3 as a regulator of invasion modality and metastasis in prostate cancer by controlling N-cadherin levels.

bioRxiv · Apr 25, 2022Cell Biology