H. Ni

Caveolar Compartmentalization is Required for Stable Rhythmicity of Sinus Nodal Cells and is Disrupted in Heart Failure

This study shows caveolae compartmentalize key proteins in SAN pacemaking, and their disruption leads to heart failure-related arrhythmias.

Enhanced Ca2+-Driven Arrhythmias in Female Patients with Atrial Fibrillation: Insights from Computational Modeling

This study uses computational models to show female atrial cardiomyocytes in AF have higher Ca2+-driven arrhythmia risk than males, with specific interventions identified to address these differences.

Degradation of indole-3-acetic acid by plant-associated microbes

This study identifies bacterial isolates capable of degrading indole-3-acetic acid (IAA) from Arabidopsis and rice roots, revealing their functional roles and association with IAA producers.

Tumors cells with mismatch repair deficiency induce hyperactivation of Pyroptosis resistant to cell membrane damage but are more sensitive to Co-treatment of IFN-γ and TNF-α to PANoptosis

The paper shows that dMMR tumor cells are resistant to membrane damage but sensitive to IFN-γ and TNF-α co-treatment inducing PANoptosis, suggesting a strategy to enhance ICB therapy.

Dual effects of the small-conductance Ca2+-activated K+ current on human atrial electrophysiology and Ca2+-driven arrhythmogenesis: an in silico study

This study uses in silico models to show that modulating the SK current in human atrial myocytes can both promote and prevent arrhythmias depending on the underlying mechanism.

Stimulated Raman Photothermal Microscopy towards Ultrasensitive Chemical Imaging

This paper introduces a new spectroscopic imaging method that improves signal intensity by over 500-fold for chemical imaging.

Multiplatform Modeling of Atrial Fibrillation Identifies Phospholamban as Central Regulator of Cardiac Rhythm

This paper develops a multi-model platform to study atrial fibrillation-associated genes, identifying phospholamban as a key regulator of cardiac rhythm through interactions with calcium handling proteins.

Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: II. Ca2+-handling protein variation

This paper uses a 3D human atrial myocyte model to study how changes in Ca2+-handling proteins and TATS density affect arrhythmia mechanisms in disease.

Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse-axial tubule variation

This study develops a 3D human atrial myocyte model to investigate how variations in transverse-axial tubule systems (TATS) affect Ca2+ handling and promote arrhythmia through spontaneous Ca2+ release.

mRNA-based vaccines against SARS-CoV-2 do not stimulate interferon stimulatory gene expression in individuals affected by Aicardi Goutieres Syndrome.

This study investigates whether mRNA-based SARS-CoV-2 vaccines induce interferon responses in individuals with Aicardi Goutieres Syndrome (AGS) and finds no significant increase in interferon signatures.

Integrative human atrial modeling unravels interactive PKA and CaMKII signaling as key determinant of atrial arrhythmogenesis

This paper develops a computational framework to simulate human atrial electrophysiology and Ca2+-handling, revealing synergistic PKA and CaMKII signaling as key drivers of atrial arrhythmogenesis.

Structure of IgG-Fc hexamer reveals a mutual lock-and-key mode of Fc-Fc interaction

The paper determines the structure of an IgG-Fc hexamer using cryo-EM, revealing a mutual lock-and-key interaction mode between Fc domains.

A tug of war between filament treadmilling and myosin induced contractility generates actin rings

The paper uses simulations and experiments to show that actin ring formation in cells depends on the balance between filament treadmilling and myosin contractility.

Sex-specific classification of drug-induced Torsade de Pointes susceptibility using cardiac simulations and machine learning

This paper develops sex-specific TdP risk classifiers using cardiac simulations and machine learning, finding that male-based models underestimate female TdP risk.

AIE nanoparticles camouflaged with tumor cell-derived exosomes for NIR-II imaging-guided photothermal therapy

This paper develops hybrid nanovesicles combining tumor exosomes and AIE nanoparticles for enhanced NIR-II imaging and photothermal therapy of tumors.

Membrane-MEDYAN: Simulating Deformable Vesicles Containing Complex Cytoskeletal Networks

The paper introduces a computational model to simulate deformable vesicles with complex cytoskeletal networks, showing how actin filament bundling influences membrane protrusion dynamics.

Species packing and the latitudinal gradient in beta-diversity

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

Biologically excretable AIE dots for visualizing through the marmosets intravitally: horizons in future clinical nanomedicine

This study designs excretable AIE dots for deep-tissue imaging in marmosets, demonstrating their biocompatibility and excretion capabilities.

Analysis of metagenome-assembled genomes from the mouse gut microbiota reveals distinctive strain-level characteristics

This study identifies strain-level features of the mouse gut microbiota using metagenome-assembled genomes, revealing distinct genomic and functional characteristics compared to human gut microbes.

Circadian control of intrinsic heart rate via a sinus node clock and the pacemaker channel

The paper shows that the intrinsic heart rate has a circadian rhythm driven by a local clock in the sinus node, regulating Hcn4 expression and funny current.

Colonization of phosphate-solubilizing Pseudomonas sp. strain P34-L in the wheat rhizosphere and its effects on wheat growth and the expression of phosphate transporter gene TaPT4 in wheat

This study isolates and characterizes a wheat-specific phosphate-solubilizing Pseudomonas strain, showing its ability to colonize the wheat rhizosphere, enhance growth, and downregulate the phosphate transporter gene TaPT4.