Author

P. P. Rocha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Sastre-Perona· 1 shared A. Singh· 1 shared B. Aranda Orgilles· 1 shared C. Zhao· 1 shared D. Herranz· 1 shared E. Chiles· 1 shared H. Khiabanian· 1 shared H. Zheng· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Sastre-Perona

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2 papers

Recent·Most cited

A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-cell Leukemia

O. Lancho, A. Singh, V. da Silva-Diz, L. Tottone, P. Renck Nunes, M. Aleksandrova, J. Khatun, S. Luo, C. Zhao, H. Zheng, E. Chiles, Z. Zuo, P. P. Rocha, X. Su, H. Khiabanian, D. Herranz

This paper identifies a NOTCH1-SIRT1-KAT7 axis in T-ALL that promotes leukemia and resistance to therapy, suggesting new therapeutic targets.

bioRxiv · May 21, 2022Cancer Biology

SOX2-phosphorylation toggles a bistable differentiation-switch in squamous cell carcinoma

S. Hoang-Phou, A. Sastre-Perona, M. Abbruzzese, Z. Ying, J. Siegle, B. Aranda Orgilles, P. P. Rocha, I. Aifantis, J. Skok, S. Beronja, M. Schober

This paper identifies a mechanism by which SOX2-phosphorylation toggles a bistable differentiation switch in squamous cell carcinoma, enabling tumor-propagating cells to transition from self-renewal to differentiation.

bioRxiv · Aug 18, 2021 · PreprintCancer Biology