DNA damage response signaling is crucial for effective Chikungunya virus replication
S. Chatterjee, S. Kumar, P. Mamidi, A. Datey, S. Sengupta, C. Mahish, E. Laha, S. De, S. S. Keshry, T. K. Nayak, S. Ghosh, S. Singh, B. B. Subudhi, S. Chattopadhyay, S. Chattopadhyay
This study shows that Chikungunya virus (CHIKV) infection activates DNA damage response (DDR) pathways, increases DNA damage, and interacts with Chk2 and Chk1 to facilitate viral replication and cell cycle arrest.
bioRxiv · Apr 12, 2022Microbiology