E. Munro

Oligomerization and positive feedback on membrane recruitment encode dynamically stable PAR-3 asymmetries in the C. elegans zygote.

The paper shows how PAR-3 asymmetry in C. elegans embryos is stabilized by two positive feedback loops involving oligomerization and membrane recruitment.

Oligomerization of peripheral membrane proteins provides tunable control of cell surface polarity

This paper shows how oligomerization of peripheral membrane proteins enables tunable non-linear feedback for stable cell surface polarity through size-dependent binding and mobility.

Actin bundle architecture and mechanics regulate myosin II force generation

This study investigates how actin bundle architecture and mechanics influence myosin II force generation through microscopy and simulations.

Pulsatile contractions and pattern formation in excitable actomyosin cortex

This study develops a reaction-diffusion model to investigate how mechanochemical feedback in the actin cortex generates pulsatile contractions and pattern formation.

Existing actin filaments orient new filament growth to provide structural memory of filament alignment during cytokinesis

The paper shows that existing actin filaments guide new filament growth during cytokinesis, enabling alignment despite rapid filament turnover.

Germline RNA helicases couple RNA binding to P granule assembly at nuclear periphery

This study shows that germline RNA helicases regulate P granule formation and disassembly through RNA binding and release, with FGG repeats promoting perinuclear localization, and links defects in this process to fertility issues in C. elegans.

RhoA mediates epithelial cell shape changes via mechanosensitive endocytosis

This study shows RhoA controls epithelial cell shape through mechanosensitive endocytosis, requiring formin and dynamin, and develops a vertex model to explain junction remodeling.