C. Lang

Rapid enzymatic detection of Shigatoxin-producing E. coli using fluorescence-labeled oligonucleotide substrates

This paper develops a rapid method to detect Shigatoxin-producing E. coli by measuring Stx activity using fluorescent oligonucleotide substrates.

Structure-function relationships underpin disulfide loop cleavage-dependent activation of Legionella pneumophila lysophosholipase A PlaA

This study reveals the structural basis for the regulated activation and substrate preference of PlaA, a lysophospholipase in Legionella pneumophila, showing how disulfide loop cleavage enhances catalytic activity and substrate specificity.

Recent O-antigen diversification masks highly pathogenic STEC O104:H4

The paper identifies genomically similar, highly pathogenic STEC strains with diverse O-antigens, masking their potential risk due to rare serotypes.

Triterpenoid production with a minimally engineered Saccharomyces cerevisiae chassis

This paper engineers Saccharomyces cerevisiae to produce triterpenoids at high titers by modifying an oxidosqualene cyclase, demonstrating a chassis for diverse triterpenoid synthesis.

NAD(H)-mediated tetramerization controls the activity of Legionella pneumophila phospholipase PlaB

This study identifies an NAD(H)-mediated tetramerization mechanism that regulates the activity and localization of the Legionella pneumophila phospholipase PlaB.

Direct Antimicrobial Resistance Prediction from clinical MALDI-TOF mass spectra using Machine Learning

This study uses machine learning to predict antimicrobial resistance from MALDI-TOF mass spectra, achieving high AUROC values and showing potential to improve clinical treatment decisions.

Germline RNA helicases couple RNA binding to P granule assembly at nuclear periphery

This study shows that germline RNA helicases regulate P granule formation and disassembly through RNA binding and release, with FGG repeats promoting perinuclear localization, and links defects in this process to fertility issues in C. elegans.

Effect of different forage-to-concentrate ratios on the structure of rumen bacteria and its relationship with nutrition levels and real-time methane production in sheep

This study examines how varying forage-to-concentrate ratios in sheep diets affect rumen bacterial structure, nutrient levels, and methane production, identifying key bacterial genera correlated with these factors.