Y. Levin

Elucidating early intestinal stem cell response to bacterial infection

This study investigates how Lgr5+ intestinal stem cells respond to Salmonella infection by initiating cellular remodeling and antimicrobial defense mechanisms.

A new cellular platform for studying autophagy

This paper introduces a CRISPR-based platform to study GABARAP proteins in autophagy, revealing their distinct associations with autophagosomes.

Antibiotics damage the colonic mucus barrier in a microbiota-independent manner

This study shows antibiotics damage the colonic mucus barrier independently of microbiota, leading to bacterial penetration and IBD exacerbation.

Loss-of-function cancer-associated mutations in the EIF4G2 non-canonical translation initiation factor

The paper investigates EIF4G2 mutations in cancer, showing some mutations impair its non-canonical translation initiation function, suggesting potential tumor suppressor roles.

Controllable self-replicating RNA vaccine delivered intradermally elicits predominantly cellular immunity

This paper develops a temperature-controlled self-replicating RNA vaccine that elicits cellular immunity and can be used as a pan-coronavirus booster.

Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischaemic injury

This study investigates the redifferentiation process in adult mouse hearts after dedifferentiation, finding residual dedifferentiation signatures and protective effects against ischemic injury.

The proteasome regulator PSME4 drives immune evasion and abrogates anti-tumor immunity in NSCLC

This paper identifies PSME4 as a proteasome regulator that suppresses anti-tumor immunity in NSCLC by inhibiting immunoproteasome activity and antigen presentation.

Widespread Utilization of Diverse Organophosphate Pollutants by Marine Bacteria

Marine bacteria utilize diverse organophosphate pollutants as a phosphorus source, offering potential for bioremediation.

SPEAR: a proteomics approach for simultaneous protein expression and redox analysis

SPEAR quantifies cysteine oxidation states and protein abundance in Arabidopsis under steady-state and oxidative stress, revealing widespread redox effects on cellular functions.

Uncovering the modified immunopeptidome reveals insights into principles of PTM-driven antigenicity

The paper identifies thousands of novel cancer-specific antigens by analyzing PTMs in immunopeptidomics data from multiple sources and reveals their impact on HLA binding and TCR recognition.

The Serine Protease HtrA2 mediates radiation-induced senescence in cancer cells

This study identifies HtrA2 as a mediator of radiation-induced senescence in cancer cells, showing its role in proliferation arrest and vimentin filament reorganization.

A nuclear role for ARGONAUTE-2 in regulation of neuronal alternative polyadenylation

This study shows AGO2 regulates alternative polyadenylation in neuronal cells, affecting Ret mRNA isoforms and GDNF signaling in motor neurons.

CSNAP, the smallest CSN subunit, modulates proteostasis through cullin-RING ubiquitin ligases

This study identifies CSNAP as a key subunit of the CSN complex that modulates CRL activity through steric inhibition, affecting cell viability and DNA damage response.

Expression of a recombinant, 4’-Phosphopantetheinylated, active M. tuberculosis Fatty acid Synthase I in E. coli

This paper describes the expression and activation of Mtb FAS I in E. coli using AcpS, confirming its biochemical activity and structural properties.