E. Semenova

Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation

This study shows that 14-3-3ζ binding to phosphorylated Tau reduces its association with microtubules and inhibits aggregation and condensation.

Identification of an anti-CRISPR protein that inhibits the CRISPR-Cas type I-B system in Clostridioides difficile

This study identifies AcrIB2, an anti-CRISPR protein from a C. difficile phage that inhibits the type I-B CRISPR-Cas system, showing that a partial cas operon is sufficient for interference.

tRNA anticodon cleavage by target-activated CRISPR-Cas13a effector

The paper shows that Cas13a cleaves tRNA anticodons to induce bacterial dormancy and activates toxin-antitoxin modules for mRNA and rRNA cleavage.

Long-Term Persistence of Plasmids Targeted by CRISPR Interference in Bacterial Populations

The paper shows plasmids can persist in E. coli under continuous CRISPR targeting without genetic changes, due to stochastic processes and plasmid replication dynamics.

Flexible fitting of PROTAC concentration-response curves with changepoint Gaussian Processes

This paper introduces a Bayesian changepoint Gaussian Processes model to automatically fit PROTAC concentration-response curves, enabling accurate parameter estimation and compound ranking without manual intervention.

A Bayesian neural network for toxicity prediction

This paper introduces a Bayesian neural network for toxicity prediction, showing it outperforms traditional models in capturing ordinal data uncertainty.

Determining organ weight toxicity with Bayesian causal models: Improving on the analysis of relative organ weights

The paper proposes using Bayesian causal models to improve the analysis of organ weight toxicity by addressing limitations in traditional methods like relative organ weight and ANCOVA.

Detection of Spacer Precursors Formed In Vivo During Primed CRISPR Adaptation

The paper develops a method to detect spacer precursors formed during primed CRISPR adaptation in vivo and identifies their structural and functional characteristics.

Alanine scanning mutagenesis of the Suvratoxumab epitope reduces alpha toxin lytic activity in vitro and S. aureus fitness in infection models

The paper mutates nine residues in the Suvratoxumab epitope of alpha toxin, showing reduced lytic activity and bacterial fitness, supporting the epitope's role in toxin function.