Author

F. Ay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

P. Vijayanand· 3 shared A. Madrigal· 2 shared C. Ottensmeier· 2 shared G. Seumois· 2 shared A. Alzetani· 1 shared A. Chakraborty· 1 shared A. Grifoni· 1 shared A. Kusnadi· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

P. Vijayanand

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Author profile →

5 papers

Recent·Most cited

Atypical B cells consist of subsets with distinct effector functions

R. A. Reyes, G. Batugedara, P. Dutta, A. Reers, R. Garza, I. Ssewanyana, P. Jagannathan, M. E. Feeney, B. Greenhouse, S. Bol, F. Ay, E. M. Bunnik

The paper identifies three distinct subsets of atypical B cells with unique transcriptional and functional profiles in individuals with chronic Plasmodium falciparum exposure.

bioRxiv · Sep 28, 2022Immunology

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.

B. J. Schmiedel, V. Chandra, J. Rocha, C. Gonzalez-Colin, S. Bhattacharyya, A. Madrigal, C. H. Ottensmeier, F. Ay, P. Vijayanand

The paper identifies COVID-19 risk variants associated with gene expression in multiple immune cell types, revealing potential mechanisms linking genetic risk to disease severity.

bioRxiv · Dec 1, 2020Immunology

Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4+ T cells

B. J. Meckiff, C. Ramirez-Suastegui, V. Fajardo, S. J. Chee, A. Kusnadi, H. Simon, A. Grifoni, E. Pelosi, D. Weiskopf, A. Sette, F. Ay, G. Seumois, C. Ottensmeier, P. Vijayanand

This study analyzes single-cell transcriptomes of SARS-CoV-2 reactive CD4+ T cells in COVID-19 patients, finding differences in cell types and gene expression between severe and mild disease.

bioRxiv · Jun 12, 2020Immunology

CD4+ follicular helper-like T cells are key players in anti-tumor immunity

D. Singh, A. P. Ganesan, B. Panwar, S. Eschweiler, C. Hanley, A. Madrigal, C. Ramirez Suastegui, A. Wang, J. Clarke, O. Wood, E. M. Garrido-Martin, S. Chee, G. Seumois, S. Belanger, A. Alzetani, , P. Vijayanand

The paper identifies CD4+ follicular helper-like T cells as critical for enhancing anti-tumor CD8+ T cell responses and tumor growth inhibition.

bioRxiv · Jan 8, 2020 · PreprintImmunology

TET enzymes augment AID expression via 5hmC modifications at the Aicda superenhancer

C.-W. J. Lio, V. Shukla, D. Samaniego-Castruita, E. Gonzalez-Avalos, A. Chakraborty, X. Yue, D. G. Schatz, F. Ay, A. Rao

This study shows TET enzymes enhance Aicda expression by depositing 5hmC at its superenhancer, promoting chromatin accessibility and CSR in B cells.

bioRxiv · Oct 8, 2018 · PreprintImmunology