X. Yue

This study identifies ABCF1 as a host protein that interacts with cccDNA, forming phase-separated condensates to suppress HBV replication through innate immune activation and transcription inhibition.

The paper uses patient-derived organoids to model metastatic neuroendocrine carcinoma of the cervix and guide personalized treatment based on drug screening.

This paper develops a multiscale model for ion transport in multicellular tissues and applies it to study smooth muscle cell activation under various stimuli, showing the importance of gap junctions and extracellular potassium.

This study shows that tolcapone causes embryo lethality and preeclampsia-like phenotypes in mice by inhibiting trophoblast migration and invasion.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.

This study shows that maternal obesity alters breast extracellular matrix collagen structure, increasing mammary epithelial cell migration and invasion.

The paper develops a proteomics-based classifier to predict lymph node metastasis in T1 colorectal cancer using protein expression patterns and machine learning.

This study shows that brassinosteroid signaling and zinc accumulation in tomato mediate a constitutive phosphate deprivation response, offering a new strategy for plant adaptation to phosphate starvation.

This study identifies OGT's role in maintaining cell viability by regulating the proteasome/mTOR/mitochondrial axis through amino acid homeostasis and mitochondrial fitness.

This study identifies Rnd3 as a protective factor in placental mitochondria through PPARγ-UCP2 signaling, showing its role in mitigating oxidative stress in preeclampsia.

This study evaluates serum exosomal miR-23a and miR-23b as biomarkers for diagnosing coronary heart diseases, finding miR-23a is downregulated and predictive of stable angina and AMI.

This study shows that primary cilia on MC4R-expressing neurons are essential for MC4R's role in controlling food intake and body weight.

This study shows that aged breast ECM drives mammary epithelial cells to an invasive, cancer-like phenotype through mechanisms involving EMT and LOX.

This study examines how cellular and ECM aging affect iPSC-derived cardiomyocyte function, maturity, and stress response, finding that ECM aging accelerates cellular aging and impairs cardiac function.

This study shows that loss of TET2 and TET3 in regulatory T cells leads to immune dysfunction and inflammation in mice.