A. Grifoni

Chikungunya-virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans

This study identifies CHIKV-specific CD4+ T cell responses in chronic CHIKVD patients, showing stronger responses and Th17 enrichment compared to resolved infection.

Early antiviral CD4 and CD8 T cell responses and antibodies are associated with upper respiratory tract clearance of SARS-CoV-2

The paper examines early T cell and antibody responses in COVID-19 patients and finds they correlate with reduced SARS-CoV-2 viral RNA in the upper respiratory tract.

Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies

The paper examines immune responses in vaccinated individuals during SARS-CoV-2 breakthrough infection, showing early activation of memory T cells and subsequent neutralizing antibody production.

Targets and cross-reactivity of human T cell recognition of Common Cold Coronaviruses

This study identifies T cell epitopes and cross-reactivity patterns across common cold coronaviruses, highlighting conservation and limitations in cross-reactivity among subgenera.

Defining antigen targets to dissect vaccinia virus (VACV) and Monkeypox virus (MPXV)-specific T cell responses in humans

The paper predicts MPXV T cell epitopes using VACV epitope data and identifies immunodominant targets to design peptide pools for detecting cross-reactive T cells in vaccinated individuals.

Unaltered T cell responses to common antigens in individuals with Parkinson's disease

This study compares T cell responses to common antigens in Parkinson's disease patients and healthy controls, finding no significant differences in antigen-specific T cell activation or cytokine production.

Humoral and cellular immune memory to four COVID-19 vaccines

This study evaluates immune memory responses to four COVID-19 vaccines over six months, finding stable T and B cell memory but declining neutralizing antibodies with mRNA vaccines.

Durable protection against SARS-CoV-2 Omicron induced by an adjuvanted subunit vaccine

This study shows that an adjuvanted subunit vaccine provides durable protection against SARS-CoV-2 Omicron in non-human primates, with strong neutralizing antibodies and memory T/B cells after booster doses.

Immunological memory to Common Cold Coronaviruses assessed longitudinally over a three-year period

The paper assesses immunological memory to Common Cold Coronaviruses over three years and finds sustained CD4+ T cell and antibody responses, suggesting stable memory rather than frequent reinfections.

SARS-CoV-2 vaccination induces immunological memory able to cross-recognize variants from Alpha to Omicron

This study shows that SARS-CoV-2 vaccines induce T cell responses that cross-recognize variants from Alpha to Omicron, with high preservation of CD4+ and CD8+ T cell epitopes.

Distinguishing COVID-19 infection and vaccination history by T cell reactivity

This study develops a T cell-based method to distinguish between SARS-CoV-2 infection and vaccination by analyzing T cell reactivity to specific epitopes, achieving high classification accuracy across different groups.

mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern

This study shows that mRNA vaccination generates durable immune memory against SARS-CoV-2 and variants of concern, with continued evolution of B and T cell responses for at least 6 months.

Profiling Human CMV-specific T cell responses reveals novel immunogenic ORFs

The paper identifies 235 unique HCMV-specific T cell epitopes, including 41 from recently described novel ORFs, revealing a broader T cell response to HCMV than previously known.

Rapid induction of antigen-specific CD4+ T cells guides coordinated humoral and cellular immune responses to SARS-CoV-2 mRNA vaccination

This study shows that mRNA vaccination rapidly induces antigen-specific CD4+ T cells, which coordinate humoral and cellular immune responses, with booster doses enhancing T cell responses in naive individuals.

Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees.

The paper analyzes T cell responses to SARS-CoV-2 variants and finds minimal impact on CD4+ and CD8+ T cell reactivity in convalescents and vaccinees.

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

The paper identifies SARS-CoV-2 epitopes recognized by CD4+ and CD8+ T cells in COVID-19 patients and develops epitope megapools for their detection.

Immunological memory to SARS-CoV-2 assessed for up to eight months after infection

The paper assesses SARS-CoV-2 immune memory components over eight months post-infection, finding varying kinetics in antibodies, B cells, and T cells.

Identification and characterization of CD4+ T cell epitopes after Shingrix vaccination.

This study identifies and characterizes CD4+ T cell epitopes specific to Shingrix vaccination, showing a shift in immunodominance from non-structural proteins to gE and mapping HLA restrictions for these epitopes.

Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4+ T cells

This study analyzes single-cell transcriptomes of SARS-CoV-2 reactive CD4+ T cells in COVID-19 patients, finding differences in cell types and gene expression between severe and mild disease.

Candidate targets for immune responses to 2019-Novel Coronavirus (nCoV): sequence homology- and bioinformatic-based predictions

The paper identifies potential immune targets for 2019-nCoV using sequence homology and bioinformatic predictions.

T cell responses induced by attenuated flavivirus vaccination are specific and show limited cross-reactivity with other flavivirus species.

This study shows that T cell responses to flavivirus vaccines are specific and have limited cross-reactivity with other flavivirus species.