Author

L. Kenner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 8 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:bulk RNA-seq· 6 Research Focus:cell type annotation· 6 Organism:human· 6 Research Focus:differential expression· 5 Organism:mouse· 5 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3

Frequent Co-Authors

G. Egger· 4 shared H. A. Neubauer· 4 shared M. Schlederer· 4 shared R. Moriggl· 4 shared C. Sternberg· 3 shared M. Oberhuber· 3 shared O. Merkel· 3 shared S. Lagger· 3 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersCancer Biology

G. Egger

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Cell-autonomous GP130 activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment

C. Sternberg, T. Limberger, M. Raigel, K. Trachtova, M. Schlederer, D. Lindner, P. Kodajova, J. Yang, R. Ziegler, H. A. Neubauer, S. Dey, T. Redmer, S. Stoiber, V. Hejret, B. Tichy, , L. Kenner

This study shows that activating GP130 in prostate epithelial cells suppresses tumor growth through senescence and immune activation, suggesting a new therapeutic approach.

bioRxiv · Feb 11, 2024 · PreprintCancer Biology

JUN mediates senescence and immune cell recruitment to prevent prostate cancer progression

T. Redmer, M. Raigel, C. Sternberg, R. Ziegler, C. Probst, D. Lindner, A. Aufinger, T. Limberger, K. Trachtova, P. Kodajova, S. Hoegler, M. Schlederer, S. Stoiber, M. Oberhuber, M. Bolis, , L. Kenner

This study shows JUN suppresses prostate cancer progression by inducing senescence and immune cell recruitment, with JUN depletion accelerating tumor growth.

bioRxiv · Nov 29, 2023 · PreprintCancer Biology

Small molecule STAT3/5 inhibitors exhibit therapeutic potential in acute myeloid leukemia and extra-nodal natural killer/T cell lymphoma

D. Pölöske, H. Sorger, A. Schönbichler, E. D. de Araujo, H. A. Neubauer, A. Orlova, S. H. Timonen, D. I. Abdallah, A. Ianevski, H. Kuusanmäki, M. Surbek, C. Wagner, T. Suske, M. L. Metzelder, M. Bergmann, , R. Moriggl

This study evaluates small molecule STAT3/5 inhibitors for treating AML and NKCL, showing growth arrest and synergy with existing therapies in vitro and in vivo.

bioRxiv · Oct 12, 2023 · PreprintCancer Biology

STAT3 cooperates with the core transcriptional regulatory circuitry to drive MYC expression and oncogenesis in anaplastic large cell lymphoma

N. Prutsch, S. He, A. Berezovskaya, A. D. Durbin, N. V. Dharia, K. Stegmaier, J. D. Matthews, L. Hare, S. D. Turner, L. Kenner, O. Merkel, R. A. Young, B. J. Abraham, A. T. Look, M. W. Zimmerman

This study identifies STAT3's role in driving MYC expression and oncogenesis in ALCL by cooperating with a core transcriptional regulatory circuit.

bioRxiv · Aug 31, 2022 · PreprintCancer Biology

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pigmentation pathway

A. Swoboda, R. Soukup, K. Kinslechner, B. Wingelhofer, D. Schoerghofer, C. Sternberg, H. Pham, M. Vallianou, J. Horvath, D. Stoiber, L. Kenner, L. Larue, V. Poli, F. Beermann, T. Yokota, , R. Moriggl

This study shows that STAT3 promotes melanoma metastasis by repressing the MITF pigmentation pathway through CEBP induction.

Oncogene · Dec 15, 2020Peer-reviewedCancer Biology

Requirement of DNMT1 to orchestrate epigenomic reprogramming during NPM-ALK driven T cell lymphomagenesis

E. Redl, R. Sheibani-Tezerji, P. Hamminger, G. Timelthaler, M. R. Hassler, S. Lagger, T. Dillinger, L. Hofbauer, M. Zrimsek, A. Tiefenbacher, M. Kothmayer, C. H. Dietz, B. H. Ramsahoye, L. Kenner, C. Bock, , G. Egger

This study shows that DNMT1 is essential for maintaining tumor-specific methylation during NPM-ALK driven T cell lymphomagenesis, despite oncogenic signaling.

bioRxiv · Apr 9, 2020 · PreprintCancer Biology

Cold-mediated regulation of systemic retinol transport controls adipose tissue browning

A. Fenzl, O. C. Kulterer, K. Spirk, G. Mitulovic, R. Marculescu, M. Bilban, S. Baumgartner-Parzer, A. Kautzky-Willer, L. Kenner, J. Plutzky, L. Quadro, F. W. Kiefer

This study shows that cold exposure increases retinol and its transporter RBP in mice and humans, promoting adipose tissue browning and thermogenesis.

bioRxiv · Feb 7, 2020 · PreprintPhysiology

Thyroid and androgen receptor signaling are antagonized by CRYM in prostate cancer

O. Aksoy, J. Pencik, M. Hartenbach, A. A. Moazzami, M. Schlederer, T. Balber, B. Mazumder, J. Whitchurch, C. J. Roberts, M. Susani, M. Mitterhauser, R. Marculescu, G. Kramer, S. D. Turner, S. Hartenbach, , L. Kenner

This study shows that CRYM antagonizes thyroid and androgen signaling in prostate cancer and correlates with prognosis and PET imaging biomarkers.

bioRxiv · Dec 19, 2019Cancer Biology

STAT3-dependent systems-level analysis reveals PDK4 as an independent predictor of biochemical recurrence in prostate cancer

M. Oberhuber, M. Pecoraro, M. Rusz, G. Oberhuber, M. Wieselberg, P. Haslinger, E. Gurnhofer, J. Pencik, R. Wiebringhaus, M. Schlederer, T. Weiss, M. Schmeidl, A. Haitel, M. J. Brehme, W. Wadsak, , L. Kenner

The paper identifies PDK4 as an independent prognostic marker for prostate cancer recurrence using gene co-expression networks and proteomics data.

bioRxiv · Sep 19, 2019Cancer Biology