Author

F. Lima

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Animal Behavior & Cognition· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell-cell communication· 2 Assay:behavioral assay· 1

Frequent Co-Authors

F. Bednar· 3 shared W. Du· 3 shared Y. Zhang· 3 shared A. Rao· 2 shared C. A. Lyssiotis· 2 shared C. Espinoza· 2 shared K. L. Donahue· 2 shared M. Pasca Di Magliano· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

F. Bednar

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesions

E. S. Carpenter, A. M. Elhossiny, P. Kadiyala, J. Li, J. McGue, B. Griffith, Y. Zhang, J. Edwards, S. Nelson, F. Lima, K. L. Donahue, W. Du, A. C. Bischoff, D. Alomari, H. Watkoske, , M. Pasca Di Magliano

The paper analyzes donor pancreata to define the transcriptomic signature and microenvironment of early pre-neoplastic lesions, finding PanIN lesions are common in healthy individuals and show transcriptional similarity to cancer cells.

bioRxiv · Jan 13, 2023 · PreprintCancer Biology

Arginase 1 is a key driver of immune suppression in pancreatic cancer

R. E. Menjivar, Z. C. Nwosu, W. Du, K. Donahue, C. Espinoza, K. Brown, A. Velez, W. Yan, F. Lima, A. Bischoff, P. Kadiyala, D. Salas-Escabillas, C. J. Halbrook, F. Bednar, E. Carpenter, , M. di Magliano

This study shows that Arginase 1 suppresses immune responses in pancreatic cancer by inhibiting T cell activation, and targeting it enhances immunotherapy effectiveness.

bioRxiv · Jun 21, 2022Cancer Biology

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming.

A. Velez-Delgado, K. L. Donahue, K. L. Brown, W. Du, V. Irizarry-Negron, R. E. Menjivar, E. L. Lasse-Opsahl, N. G. Steele, S. The, J. Lazarus, V. R. Sirihorachai, W. Yan, S. B. Kemp, S. A. Kerk, M. Bollamplly, , M. Pasca di Magliano

This study shows that extrinsic KRAS signaling reprograms pancreatic fibroblasts to create an inflammatory microenvironment that supports tumor growth.

bioRxiv · Aug 26, 2021Cancer Biology

SLIT2-ROBO signaling in tumor-associated microglia/macrophages drives glioblastoma immunosuppression and vascular dysmorphia

L. H. Geraldo, Y. Xu, L. Jacob, L. Pibouin-Fragner, R. Rao, N. Maissa, M. Verreault, N. Lemaire, C. Knosp, C. Lesaffre, T. Daubon, J. Dejaegher, L. Solie, J. Rudewicz, T. Viel, , T. Mathivet

This study shows that SLIT2-ROBO signaling in tumor-associated microglia/macrophages promotes glioblastoma immunosuppression and vascular dysmorphia, and its inhibition reduces tumor growth and enhances therapy.

bioRxiv · Apr 12, 2021Cancer Biology

Conditional approach as cooperation in predator inspection: a role for serotonin?

A. F. N. Pimentel, T. d. S. Carvalho, F. Lima, M. G. Lima-Maximino, M. C. Soares, C. Maximino

This study investigates whether serotonin modulates conditional approach behavior in guppies during predator inspection, finding that serotonin increases inspection time and decreases avoidance.

bioRxiv · Mar 1, 2019Animal Behavior & Cognition