Combined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy.
K. Fujita, P. Desmond, J. Blondelle, M. Sotak, M. R. Rajan, M. Clark, E. Esteve, Y. Chan, Y. Gu, V. Marrocco, N. D. Dalton, M. Ghassemian, A. Do, M. Klos, K. L. Peterson, , S. Lange
This study shows that loss of obscurin and Obsl1 in mice causes diastolic dysfunction, altered metabolism, and deregulated mitophagy in the heart.
bioRxiv · Aug 24, 2022 · PreprintCell Biology