G. Cooper

Targeting MLL methyltransferases enhance the anti-tumor effects of PI3K inhibition in hormone receptor-positive breast cancer

This paper shows that combining PI3K and MLL1 inhibition enhances anti-tumor effects in HR+ breast cancer by disrupting a feedback loop between MLL1 and AKT.

Does the evolution of division of labour require accelerating returns from individual specialisation?

The paper investigates factors favoring the evolution of reproductive division of labour in topologically constrained groups and finds it requires coordination and efficiency benefits, but not necessarily accelerating returns from individual specialisation.

Active synthesis of type I collagen homotrimer in Dupuytren's fibrosis is unaffected by anti-TNF-α treatment

This study investigates type I collagen synthesis in Dupuytrens disease and finds anti-TNF-α treatment does not reduce collagen production or prevent homotrimer formation.

Systematic Discovery of the Functional Impact of Somatic Genome Alterations in Individual Tumors through Tumor-specific Causal Inference

This paper introduces a tumor-specific causal inference framework to identify causative somatic genome alterations and their impact on molecular phenotypes in individual tumors.