Author

G. Deb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

G. Xiao· 2 shared J. Lee· 2 shared K. Kume· 2 shared K. N. Cosgun· 2 shared L. N. Chan· 2 shared M. E. Robinson· 2 shared T. Sadras· 2 shared Z. Chen· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

G. Xiao

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment

A. Papadas, G. Deb, A. Officer, A. Cicala, C. Hope, P. Emmerich, J. Wiesner, A. Pagenkopf, G. Arauz, V. Bansal, K. Matkowskyj, D. A. Deming, K. Politi, S. Abrams, O. Harismendy, F. Asimakopoulos

The paper shows that stromal remodeling generates signals that regulate dendritic cell survival and activity, enhancing T-cell inflammation in the tumor microenvironment.

bioRxiv · Nov 10, 2021Immunology

Lgr5-mediated restraint of β-catenin is essential for B-lymphopoiesis and leukemia-initiation

K. N. Cosgun, M. E. Robinson, G. Deb, X. Yang, G. Xiao, T. Sadras, J. Lee, L. N. Chan, K. Kume, J. Winchester, Z. Chen, L. Yang, M. Mueschen

This study identifies Lgr5's role in restraining β-catenin to support B-lymphopoiesis and shows its therapeutic potential in B-ALL by targeting β-catenin hyperactivation.

bioRxiv · Mar 12, 2020 · PreprintCancer Biology

Signaling input from divergent pathways subverts malignant B-cell transformation

L. N. Chan, M. A. Murakami, M. E. Robinson, R. Caeser, T. Sadras, J. Lee, K. N. Cosgun, K. Kume, V. Khairnar, G. Xiao, M. Ahmed, E. Aghania, G. Deb, C. Hurtz, S. Shojaee, , M. Muschen

This study shows that malignant B-cell transformation requires convergence on a single oncogenic pathway, while divergent pathways can subvert transformation and are targets for new therapeutic strategies.

bioRxiv · Mar 12, 2020Cancer Biology