In vivo optimized three-photon imaging of intact mouse tibia links plasma cell motility to functional states in the bone marrow.
R. A. Niesner, A. Rakhymzhan, A. F. Fiedler, R. Guenther, S. Domingue, L. Wooldridge, R. Leben, Y. Cao, A. Bias, J. Roodselaar, R. Koehler, C. Ulbricht, J. Heidelin, V. Andresen, I. Beckers, , A. E. Hauser
This paper develops a three-photon imaging method to study plasma cell motility and functional states in mouse bone marrow, finding an inverse link between migratory behavior and protein synthesis capacity.
bioRxiv · Dec 16, 2023 · PreprintBiophysics