Genome-wide in vivo CRISPR screens identify GATOR1 as a potent tumor suppressor in MYC-driven lymphomagenesis
M. A. Potts, S. Mizutani, Y. Deng, S. Vaidyanathan, K. Ting, G. Giner, S. Shruti, Y. Liao, S. Diepstraten, A. J. Kueh, M. Pal, G. Healey, L. Tai, Z. Wang, C. Koenig, , M. J. Herold
The paper identifies GATOR1 as a tumor suppressor in MYC-driven lymphomagenesis using in vivo CRISPR screens and shows its sensitivity to mTOR inhibitors.
bioRxiv · Feb 16, 2022 · PreprintCancer Biology