K. Sun

Therapeutic Peptide SS-31 Modulates Membrane Binding and Aggregation of Alpha-Synuclein and Restores Impaired Mitochondrial Function

This study shows SS-31 reduces alpha-synuclein membrane binding, aggregation, and mitochondrial dysfunction in neuroblastoma cells.

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

This study shows proteasome inhibition alters DNA methylation in colorectal cancer by reducing DNMT1 and DNMT3B synthesis via AKT/mTOR inactivation.

MAPK13 controls structural remodeling and disease after epithelial injury

This study identifies MAPK13 as a regulator of structural remodeling and disease after epithelial injury, showing its role in basal-epithelial stem cell hyperplasia and mucous metaplasia in both mouse and human models.

Modular Design and Scaffold-Synthesis of Multi-Functional Fluorophores for Targeted Cellular Imaging and Pyroptosis

This study designs and synthesizes functional fluorophores using a scaffold-based Ugi reaction, enabling detection of reactive-oxygen species and controlled subcellular localization, with some compounds showing pyroptosis-inducing activity in cancer cells.

Lack of the IFN-γ signal leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions

This study shows that lack of IFN-γ signaling leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions, highlighting its critical role in immune defense.

Lymphotoxin-β Promotes Bone Colonization and Osteolytic Outgrowth of Indolent Bone Metastatic cells of Breast Cancer

This study identifies lymphotoxin-β as a key factor promoting bone colonization and osteolytic outgrowth of breast cancer metastatic cells.

A structural and functional analysis of opal stop codon translational readthrough during Chikungunya Virus replication

This study investigates the role of opal stop codon translational readthrough in CHIKV replication by replacing stop codons and analyzing structural and functional effects.

Spatiotemporal Control of Genomics and Epigenomics by Ultrasound

This paper develops FUS-CRISPR(a/i) tools to remotely control gene expression and epigenetic modifications in vivo, showing therapeutic effects in tumor models.

Disease associated mutations in tau encode for changes in aggregate structure conformation

This study shows that disease-associated tau mutations alter the structure of tau aggregates, revealing new insights into their pathological mechanisms.

Innate attraction and aversion to odors in locusts

The paper investigates innate odor preferences in locusts, finding that hatchlings prefer food odor blends but have varying responses to individual components depending on concentration.

A novel interaction between the 5' untranslated region of the Chikungunya virus genome and Musashi RNA binding protein is essential for efficient virus genome replication.

This study identifies Musashi RNA binding proteins as essential for Chikungunya virus genome replication and suggests a potential therapeutic target.

Single-cell transcriptomic analyses reveal the cellular and genetic basis of aquatic locomotion in scyphozoan jellyfish

The paper was withdrawn due to the need for additional experimental evidence and reorganization of data and writing.

Extracellular disintegration of viral proteins as an innovative strategy for developing broad-spectrum antivirals against coronavirus

This paper introduces a new antiviral strategy using hyperanion-grafted enediyne molecules to disintegrate viral proteins, showing effectiveness against SARS-CoV-2 and other coronaviruses.

Wireless closed-loop smart bandage for chronic wound management and accelerated tissue regeneration

This paper develops a wireless smart bandage that monitors wound conditions and delivers electrical stimulation to accelerate tissue regeneration in chronic wounds.

Fracture healing is delayed in the absence of gasdermin signaling

This study shows that gasdermin signaling is essential for fracture healing, as its absence delays bone callus formation and reduces biomechanical properties.

Non-Invasive Skin Sampling Detects Systemically Administered Drugs in Humans

This study shows that skin swabs combined with mass spectrometry can detect systemically administered drugs and their metabolites in humans.

Accumulation of auranofin in white adipose tissues lowers leptin levels and exerts anti-diabetic effects

The paper identifies auranofin as a drug that lowers leptin levels in white adipose tissue and improves insulin sensitivity in obese mice, with anti-diabetic effects.

Label-free imaging for quality control of cardiomyocyte differentiation

The paper develops a label-free imaging method to predict cardiomyocyte differentiation efficiency from hPSCs using autofluorescence and multivariate models.

Effects of carbon, nitrogen, phosphorus, and potassium on flowering and Fruiting of Glycyrrhiza uralensis

This study investigates the effects of carbon, nitrogen, phosphorus, and potassium on flowering and fruiting of Glycyrrhiza uralensis, finding that higher levels of C, P, and K benefit flower bud differentiation, while excessive N is detrimental, and optimal N and K levels at the filling stage improve seed setting and filling.

Activation of GSDME compensates for GSDMD deficiency in a mouse model of NLRP3 inflammasomopathy

This study shows that GSDME compensates for GSDMD deficiency in NLRP3 inflammasomopathy, revealing a GSDME-dependent inflammatory pathway and suggesting dual inhibition of GSDMD and GSDME for therapeutic benefit.

Loss of phosphatidylserine flippase β-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis

This study shows that loss of Tmem30a in podocytes causes albuminuria and glomerulosclerosis in mice, with reduced TMEM30A expression observed in human podocytopathies.

Bacterial Swarmers exhibit a Protective Response to Intestinal Stress

This study identifies bacterial swarmers as protective against intestinal inflammation in mice and humans, showing their ability to enrich beneficial gut microbes.

Glutamine deprivation triggers NAGK-dependent hexosamine salvage

This study shows that glutamine deprivation in pancreatic ductal adenocarcinoma cells increases free GlcNAc and activates NAGK-dependent hexosamine salvage to support tumor growth.

KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia

This study shows that KSHV-encoded vCyclin modulates HIF1α levels in hypoxia to promote DNA replication and cell proliferation.

Accurate recognition of colorectal cancer with semi-supervised deep learning on pathological images

This paper develops a semi-supervised deep learning model for colorectal cancer recognition using pathological images, showing it outperforms supervised learning with limited labeled data and matches pathologists' performance.

Disease mutation study identifies essential residues for phosphatidylserine flippase ATP11A

The paper identifies essential residues in ATP11A for its expression and flippase activity through mutation analysis and functional assays.

Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry

This paper develops FKK6, a non-cytotoxic PXR agonist derived from microbial metabolite mimicry, which reduces inflammation and validates the strategy for drug discovery.

A new strategy for selection of crop cultivated varieties based on yield factors driving and meteorological prediction

This paper proposes a strategy to select crop varieties based on yield factors and meteorological predictions, showing 70% and 50% success rates in two pilot regions for soybean variety selection.

Transient Overexpression of VEGF-A in Adipose Tissue Promotes Energy Expenditure via Activation of the Sympathetic Nervous System

This study shows that transient VEGF-A overexpression in adipose tissue activates the sympathetic nervous system, enhancing lipolysis, browning, and energy expenditure.

Impact of exogenous nitrogen on cyanobacterial abundance and community in oil-contaminated sediment mesocosms

The paper investigates how exogenous nitrogen affects cyanobacterial abundance and community in oil-contaminated sediment mesocosms, finding nitrogen limitation drives cyanobacterial blooms in oil-contaminated environments.