Author

H. R. Keys

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

D. M. Sabatini· 2 shared A. Detappe· 1 shared A. Letai· 1 shared A. Tsherniak· 1 shared C. H. Adelmann· 1 shared C. N. Cunningham· 1 shared D. Sirohi· 1 shared G. Kugener· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

D. M. Sabatini

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 1, 2021

Co-deletion of ATAD1 with PTEN primes cells for BIM-mediated apoptosis

J. M. Winter, H. L. Fresenius, H. R. Keys…·J. Rutter

The paper shows that co-deletion of ATAD1 with PTEN makes cancer cells more susceptible to apoptosis via BIM activation, correlating with better patient survival.

DOI 10.1101/2021.07.01.450781

humanexperimental assay

𝕏 PostBluesky

Cancer BiologybioRxivAug 31, 2020

CRISPR screens in physiologic medium reveal conditionally essential genes in human cells

N. J. Rossiter, K. S. Huggler, C. H. Adelmann…·J. R. Cantor

This study uses CRISPR screens in different media to identify conditionally essential genes in human cells, showing how medium composition affects gene essentiality.

DOI 10.1016/j.cmet.2021.02.005

humangenetic perturbation / CRISPR

𝕏 PostBluesky

Cancer BiologybioRxivMar 24, 2018

Inhibition of mitochondrial ferredoxin 1 (FDX1) prevents adaptation to proteotoxic stress

P. Tsvetkov, A. Detappe, K. Cai…·S. Lindquist

This study identifies FDX1 inhibition as a strategy to prevent proteasome inhibitor resistance in cancer by targeting mitochondrial Fe-S cluster biosynthesis.

DOI 10.1038/s41589-019-0291-9

mousegenetic perturbation / CRISPR

𝕏 PostBluesky