Author

A. Detappe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

I. M. Ghobrial· 2 shared A. Tsherniak· 1 shared B. Bragantini· 1 shared C. P. Lin· 1 shared D. Chowdhury· 1 shared D. J. Schuller· 1 shared G. Cui· 1 shared G. Kugener· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBioengineering

I. M. Ghobrial

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering

G. Cui, M. V. Botuyan, P. Drane, Q. Hu, B. Bragantini, J. R. Thompson, D. J. Schuller, A. Detappe, M. T. Perfetti, L. I. James, S. V. Frye, D. Chowdhury, G. Mer

This study identifies an autoinhibited state of 53BP1 stabilized by small molecule ligands, which shift its conformational equilibrium and inhibit chromatin recruitment.

bioRxiv · Apr 20, 2023Biochemistry

In Vivo Monitoring of Rare Circulating Tumor Cell and Cluster Dissemination in a Multiple Myeloma Xenograft Model

R. Patil, X. Tan, P. Bartosik, A. Detappe, J. M. Runnels, I. M. Ghobrial, C. P. Lin, M. Niedre

This study develops a GFP-compatible DiFC method to non-invasively monitor CTC burden and detect CTC clusters in a multiple myeloma xenograft model.

bioRxiv · Jan 11, 2019Bioengineering

Inhibition of mitochondrial ferredoxin 1 (FDX1) prevents adaptation to proteotoxic stress

P. Tsvetkov, A. Detappe, K. Cai, H. R. Keys, Z. Brune, W. Ying, P. Thiru, M. Reidy, G. Kugener, A. Tsherniak, S. Santagata, L. Whitesell, J. L. Markley, I. M. Ghobrial, S. Lindquist

This study identifies FDX1 inhibition as a strategy to prevent proteasome inhibitor resistance in cancer by targeting mitochondrial Fe-S cluster biosynthesis.

bioRxiv · Mar 24, 2018Cancer Biology