C.-C. Chen

PGC-1a drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity

Timing of treatment shapes the path to androgen receptor signaling inhibitor resistance in prostate cancer

This study shows that treatment timing affects the path to androgen receptor signaling inhibitor resistance in prostate cancer, with resistance arising through different mechanisms depending on the tumor context.

Optimal Liquid-Based DNA Preservation for DNA Barcoding of Field-Collected Fungal Specimens

This study compares RNAlater and DESS for preserving fungal DNA in field conditions, finding no significant differences in DNA quality and quantity between the two methods.

The receptor binding domain of SARS-CoV-2 spike protein fused with the type IIb E. coli heat-labile enterotoxin A subunit as an intranasal booster after mRNA vaccination

This study evaluates an intranasal RBD-LTA fusion protein as a booster vaccine after mRNA vaccination, showing comparable neutralizing antibody titers and increased IgA responses against SARS-CoV-2 variants.

Targeting Ras signaling excitability in cancer cells through combined inhibition of FAK and PI3K

This study shows that combining FAK and PI3K inhibitors synergistically suppresses cervical and pancreatic cancer cell growth by increasing apoptosis and reducing mitosis.

Effect of flavonoids hydroxygenkwanin on vascular smooth muscle cell proliferation, migration, and neointimal formation

This study evaluates hydroxygenkwanin's effect on vascular smooth muscle cell proliferation, migration, and neointimal formation, finding it inhibits these processes via the PDK1/AKT/mTOR pathway and promotes endothelial progenitor cell chemotaxis.

MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

This study shows that MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer by affecting chromatin modifications and gene expression.

Phosphoantigens are Molecular Glues that Promote Butyrophilin 3A1/2A1 Association Leading to Vγ9Vδ2 T Cell Activation

The paper shows phosphoantigens glue BTN3A1 and BTN2A1 together, initiating gamma-delta T cell activation through intracellular signaling.

KRAS G12D can be targeted by potent salt-bridge forming inhibitors

This study identifies potent inhibitors targeting KRAS G12D via a salt-bridge interaction, showing efficacy in reducing tumor volume and synergizing with anti-PD-1 therapy.

Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition

This study shows that low-dose antibiotic residue exposure in early life alters gut microbiota and bile acid composition, leading to long-term metabolic disorders in mice.

LIN37-DREAM Prevents DNA End Resection and Homologous Recombination at DNA Double Strand Breaks in Quiescent Cells

The paper shows LIN37 prevents DNA end resection and HR in quiescent cells independently of 53BP1, unlike in cycling cells.

Efficient inhibition of SARS-CoV-2 strains by a novel ACE2-IgG4-Fc fusion protein with a stabilized hinge region

This paper describes a novel ACE2-IgG4-Fc fusion protein that inhibits SARS-CoV-2 strains efficiently with improved pharmaceutical properties and broad antiviral activity.

Evaluation of Compatibility of 16S rRNA V3V4 and V4 Amplicon Libraries for Clinical Microbiome Profiling

This paper evaluates the compatibility of 16S rRNA V3V4 and V4 amplicons for microbiome profiling, finding that V4O primers provide the most accurate data and that V3V4 amplicons can be compatible with V4 amplicons after trimming.

Pleiotropic win-win mutations can rapidly evolve in a nascent cooperative community despite unfavorable conditions

The paper shows that pleiotropic 'win-win' mutations can evolve rapidly in cooperative yeast communities even under unfavorable conditions by improving both self and partner fitness.

Modulation of adenine phosphoribosyltransferase-mediated salvage to promote diabetic wound healing

This study shows that adenine supplementation enhances ATP levels and accelerates wound healing in diabetic mice by modulating APRT-mediated purine salvage.

Molecular Survey for Selected Viral Pathogens in Wild Leopard Cats (Prionailurus bengalensis) in Taiwan with an Emphasis on the Spatial and Temporal Dynamics of Carnivore Protoparvovirus 1

This study detects viral pathogens in wild leopard cats in Taiwan, finding high prevalence of carnivore protoparvovirus 1 and coronavirus, with evidence of transmission from domestic carnivores.

Disentangling strictly self-serving mutations from win-win mutations in a mutualistic microbial community

The paper shows that a mutation increasing hypoxanthine release in yeast was mistakenly thought to be win-win but is actually self-serving due to increased cell size and lysine consumption.

Unprecedented Account of Mortality and Morbidity in Free Ranging Formosan Pangolin (Manis pentadactyla pentadactyla)

This paper examines mortality and morbidity factors in free-ranging Formosan pangolins in Taiwan, identifying key threats like gin traps and dog attacks, and highlights conservation success through rescue efforts.

DNAJB1-PRKACA fusion kinase interacts with β-catenin and liver regenerative response to drive fibrolamellar hepatocellular carcinoma

This study shows that the DNAJB1-PRKACA fusion kinase drives fibrolamellar hepatocellular carcinoma in mice and identifies β-catenin activation and environmental factors as contributors to tumor progression.