I. Chang

ElegansBot: Development of equation of motion deciphering locomotion including omega turns of Caenorhabditis elegans

This paper develops a kinetic model of C. elegans locomotion that reproduces various movements, including omega turns, and quantifies forces acting on body segments.

Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism

This study examines the effects of six pyrimidine analogs on Tetrahymena thermophila growth and their mechanisms of action, finding that different analogs inhibit growth through distinct sites and that some effects are reversible with specific nucleobases or nucleosides.

Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19

This study integrates plasma proteomics and single-cell immune features to classify COVID-19 severity and identify biological signatures of disease progression.

Structural and molecular insight into the pH-induced low-permeability of the voltage-gated potassium channel Kv1.2 through dewetting of the water cavity

This study identifies two residues in Kv1.2 that act as a pH switch, showing how protonation disrupts electrostatic balance and causes channel closure through dewetting of the water cavity.