Author

D. Furman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Research Focus:differential expression· 5 Assay:bulk RNA-seq· 4 Approach:statistical model· 4 Organism:mouse· 3 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Organism:human· 2

Frequent Co-Authors

C. G. Aguirre· 2 shared D. A. Winer· 2 shared F. Wu· 2 shared S. Khan· 2 shared S. Winer· 2 shared A. J. Gehring· 1 shared A. Mortha· 1 shared A. Rane· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

C. G. Aguirre

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Author profile →

5 papers

Recent·Most cited

Single-cell transcriptomics reveals colonic immune perturbations during amyloid-β driven Alzheimer's disease in mice

P. Makhijani, R. Emani, C. G. Aguirre, W.-C. Mu, A. Rane, J. H. Y. Ng, T. R. Valentino, M. Manwaring-Mueller, C. R. Tan, H. Du, F. Wu, S. Khan, K. A. Wilson, S. Winer, C. Wang, , D. A. Winer

This study uses single-cell RNA sequencing to identify immune changes in the colon of Alzheimer's disease mice, finding reduced antibody-secreting cells and altered immune trafficking.

bioRxiv · Jan 27, 2024 · PreprintImmunology

A ketogenic diet reduces age-induced chronic neuroinflammation in mice

M. Nomura, N. F. Murad, S. S. Madhavan, B. Eap, T. Y. Garcia, C. G. Aguirre, E. Verdin, L. Ellerby, D. Furman, J. C. Newman

This study shows that a cyclic ketogenic diet reduces neuroinflammation in aging mice by modulating microglial responses to inflammatory stimuli.

bioRxiv · Dec 1, 2023 · PreprintImmunology

B Cells Promote T Cell Immunosenescence and Mammalian Aging Parameters

S. Khan, M. Chakraborty, F. Wu, N. Chen, T. Wang, Y. T. Chan, A. Sayad, J.-D. S. Vasquez, M. Kotlyar, K. Nguyen, Y. Huang, F. J. Alibhai, M. Woo, R.-K. Li, M. Husain, , D. A. Winer

The paper identifies B cells as drivers of T cell immunosenescence and aging, showing that targeting B cells with CD20 antibodies can reverse age-related T cell dysfunction.

bioRxiv · Sep 12, 2023 · PreprintImmunology

Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19

D. Feyaerts, J. Hedou, J. Gillard, H. Chen, E. S. Tsai, L. S. Peterson, K. Ando, M. Manohar, E. Do, G. K. R. Dhondalay, J. Fitzpatrick, M. Artandi, I. Chang, T. T. Snow, R. S. Chinthrajah, , D. R. McIlwain

This study integrates plasma proteomics and single-cell immune features to classify COVID-19 severity and identify biological signatures of disease progression.

bioRxiv · Feb 9, 2021Immunology

An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in Humans

N. Sayed, T. Gao, R. j. Tibshirani, T. Hastie, L. Cui, T. Kuznetsova, Y. Rosenberg-Hasson, R. Ostan, D. Monti, B. Lehallier, S. Shen-Orr, H. Maecker, C. L. Dekker, T. Wyss-Coray, C. Franceschi, , D. Furman

The paper develops an inflammatory clock of aging (iAge) using blood immunome data from 1001 individuals, showing it correlates with multi-morbidity, immunosenescence, and cardiovascular aging.

bioRxiv · Nov 16, 2019 · PreprintImmunology