K. Ando

Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β

This study shows that axonal mitochondria depletion disrupts autophagy and proteostasis in neurons, mediated by the eIF2β pathway, contributing to aging and neurodegenerative diseases.

Molecular dynamics simulation analysis of structural dynamic cross correlation induced by odorant hydrogen-bonding in mouse eugenol olfactory receptor

The paper uses molecular dynamics simulations to analyze structural dynamics of the mouse eugenol olfactory receptor upon ligand binding, identifying a correlation transfer pathway induced by hydrogen bonding.

Precise immunofluorescence canceling for highly multiplexed imaging capturing specific cell state

The paper introduces PECAbs for high-specificity multiplexed imaging of cell states and combines them with seq-smFISH to classify cells and identify signal activation states in human tissue.

Coronary artery established through amniote evolution

This study investigates the evolutionary origin of coronary arteries in amniotes, showing they evolved through a new developmental process rather than being ancestral.

Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19

This study integrates plasma proteomics and single-cell immune features to classify COVID-19 severity and identify biological signatures of disease progression.

CTDSP1 inhibitor rabeprazole regulates DNA-PKcs dependent topoisomerase I degradation and irinotecan drug resistance in colorectal cancer

This study shows that rabeprazole inhibits CTDSP1, which promotes irinotecan resistance in colorectal cancer by enhancing DNA-PKcs-mediated topoisomerase I degradation.