Author
I. M. Ghobrial
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2018-2023 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 22 mutual co-author links8 papers
Recent·Most cited
- Cancer BiologybioRxivPreprint
Novel mechanism of MYC deregulation in Multiple Myeloma
M. Rahmat, K. Clement, J.-B. Alberge…·I. M. Ghobrial
The paper identifies a new epigenetic mechanism of MYC deregulation in multiple myeloma through enhancer accessibility and transcription factor binding, independent of translocations or amplifications.
DOI 10.1101/2023.05.19.541506 - Cancer BiologybioRxivPreprint
Selective Enhancer Dependencies in MYC-Intact and MYC-Rearranged Germinal Center B-cell Diffuse Large B-cell Lymphoma
A. R. Iyer, A. Gurumurthy, R. Kodgule…·R. J. Ryan
The paper identifies enhancer dependencies in MYC-intact and MYC-rearranged GCB-DLBCL using CRISPRi screens, revealing distinct regulatory mechanisms.
- Cancer BiologybioRxivPreprint
Single-cell multi-omics defines the cell-type specific impact of splicing aberrations in human hematopoietic clonal outgrowths
F. Gaiti, P. Chamely, A. G. Hawkins…·D. A. Landau
This study introduces GoT-Splice, a multi-omics method to analyze splicing aberrations in human hematopoietic cells, revealing cell-type specific effects of SF3B1 mutations in clonal outgrowths.
- Cancer BiologybioRxivPreprint
Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation
A. S. Nam, N. Dusaj, F. Izzo…·D. Landau
This study uses single-cell multi-omics to show DNMT3A R882 mutations cause hypomethylation and alter progenitor cell fates in clonal hematopoiesis.
- Cancer BiologybioRxiv
Genetic Subtypes of Smoldering Multiple Myeloma are associated with Distinct Pathogenic Phenotypes and Clinical Outcomes
M. Bustoros, S. Anand, R. Sklavenitis-Pistofidis…·I. M. Ghobrial
This study identifies six genetic subtypes of smoldering multiple myeloma associated with distinct clinical outcomes and progression risks.
DOI 10.1038/s41467-022-30694-w - BioengineeringbioRxiv
In Vivo Monitoring of Rare Circulating Tumor Cell and Cluster Dissemination in a Multiple Myeloma Xenograft Model
R. Patil, X. Tan, P. Bartosik…·M. Niedre
This study develops a GFP-compatible DiFC method to non-invasively monitor CTC burden and detect CTC clusters in a multiple myeloma xenograft model.
DOI 10.1117/1.jbo.24.8.085004 - Cancer BiologybioRxiv
Inhibition of mitochondrial ferredoxin 1 (FDX1) prevents adaptation to proteotoxic stress
P. Tsvetkov, A. Detappe, K. Cai…·S. Lindquist
This study identifies FDX1 inhibition as a strategy to prevent proteasome inhibitor resistance in cancer by targeting mitochondrial Fe-S cluster biosynthesis.
DOI 10.1038/s41589-019-0291-9