Author

I. Renard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

P. Vydyam· 4 shared C. Ben Mamoun· 3 shared A. Chattopadhyay Pal· 2 shared J. E. Chiu· 2 shared J. S. Doggett· 2 shared M. K. Riscoe· 2 shared P. Singh· 2 shared R. Dodean· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

P. Vydyam

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

In Vitro Efficacy of Next Generation Dihydrotriazines and Biguanides Against Babesiosis and Malaria Parasites

P. Vydyam, M. Chand, S. Gihaz, I. Renard, G. D. Heffernan, L. R. Jacobus, D. P. Jacobus, K. W. Saionz, R. Shah, H.-M. Shieh, J. Terpinski, W. Zhao, E. Cornillot, C. Ben Mamoun

This study screens dihydrotriazines and biguanides against Babesia and Plasmodium parasites to identify effective antifolates with broad-spectrum activity and high therapeutic indices.

bioRxiv · Mar 20, 2024Microbiology

A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in P. falciparum Malaria.

Z. M. Chahine, S. Abel, T. Hollin, J. H. Chung, G. L. Barnes, M. E. Daub, I. Renard, J. Y. Choi, P. Vydyam, A. Chattopadhyay Pal, M. Argomaniz, C. Banks, J. kirkwood, A. Saraf, I. Camino Diaz, , K. G. Le Roch

This paper identifies MED6-189, a potent antimalarial compound that disrupts apicoplast function and vesicular trafficking in P. falciparum, showing efficacy against drug-resistant strains and demonstrating a unique mechanism of action.

bioRxiv · Nov 21, 2023 · PreprintMicrobiology

Babesia duncani as a model organism to study the development, virulence and drug susceptibility of intraerythrocytic parasites in vitro and in vivo

C. Mamoun, A. C. Pal, I. Renard, P. Singh, P. Vydyam, J. E. Chiu, S. Pou, R. W. Winter, R. Dodean, L. Frueh, A. C. Nilsen, M. K. Riscoe, J. S. Doggett

This paper establishes a new in vitro and in vivo model using Babesia duncani to study parasite development, virulence, and drug susceptibility, identifying effective new therapies.

bioRxiv · Dec 1, 2021Microbiology

Effective Therapy Targeting Cytochrome bc1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection

J. E. Chiu, I. Renard, A. Chattopadhyay Pal, P. Singh, P. Vydyam, J. Thekkiniath, M. Kumar, S. Gihaz, S. Pou, R. W. Winter, R. Dodean, A. Nilsen, M. K. Riscoe, J. S. Doggett, C. Ben Mamoun

This study identifies an effective ELQ prodrug that prevents Babesia erythrocytic development and protects against lethal infection in mouse models.

bioRxiv · Mar 31, 2021Microbiology

PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma

S. D. Edge, I. Renard, E. Pyne, H. Moody, R. Roy, A. W. Beavis, S. J. Archibald, C. J. Cawthorne, S. G. Maher, I. M. Pires

This study shows that PI3K inhibition improves radiation response in oesophageal adenocarcinoma patients resistant to neo-CRT by upregulating PTEN through miR-187.

The British Journal of Radiology · Mar 1, 2021Peer-reviewedCancer Biology