Author

I. Sipula

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

M. J. Jurczak· 3 shared B. Xie· 2 shared A. B. Frias· 1 shared A. C. Poholek· 1 shared A. M. Vandevender· 1 shared A. N. Fooks· 1 shared A. Singhi· 1 shared B. A. Kaufman· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersPhysiology

M. J. Jurczak

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3 papers

Recent·Most cited

G-PROTEIN COUPLED RECEPTOR 19 (GPR19) KNOCKOUT MICE DISPLAY SEX-DEPENDENT METABOLIC DYSFUNCTION

B. A. S. Mushala, B. Xie, I. Sipula, M. W. Stoner, D. Thapa, J. R. Manning, P. Bugga, A. M. Vandevender, M. J. Jurczak, I. Scott

This study shows that GPR19 knockout mice exhibit sex-dependent metabolic dysfunction, with males showing glucose intolerance and liver enlargement on a high-fat diet.

bioRxiv · Oct 29, 2022Physiology

Blimp-1 in adipose resident Tregs controls adipocyte beiging and obesity

L. Y. Beppu, X. Qu, G. J. Marrero, A. N. Fooks, A. B. Frias, K. E. Helfrich, I. Sipula, B. Xie, S. C. Watkins, A. C. Poholek, M. J. Jurczak, L. M. D'Cruz

This study shows that Blimp-1 in adipose Tregs suppresses IL-10, reducing beiging and increasing obesity risk, while its ablation improves insulin sensitivity and reduces weight in mice.

bioRxiv · Dec 14, 2019 · PreprintImmunology

Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance

B. A. Kaufman, F. Belmonte, N. Dedousis, I. Sipula, N. Desai, A. Singhi, y. chu, Y. Zhang, S. Bannwarth, V. Paquis-Flucklinger, L. Harrington, R. M. O'Doherty, M. J. Jurczak

This study shows that PIF1 helicase deficiency in female mice on a Western diet leads to increased weight gain but not inflammation or reduced glucose clearance.

bioRxiv · Aug 16, 2018Physiology