Y. Chu

A Host Enzyme Reduces Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Inactivating Intestinal Lipopolysaccharide

This study shows that AOAH inactivates intestinal LPS, reducing MASLD by preventing hepatic lipid accumulation and altering lipid metabolism gene expression.

Biochemical characterization of extended-spectrum β-lactamases from Akkermansia genus

The paper characterizes β-lactamases from Akkermansia species, showing they exhibit extended-spectrum activity and lack transferable resistance genes.

SwinCell: a transformer-based framework for dense 3D cellular segmentation

SwinCell is a 3D transformer-based framework that improves segmentation of dense cellular images by balancing local feature recognition and contextual understanding.

Gut microbes of the cecum versus the colon drive more severe lethality and multi-organ damage

This study compares the severity of sepsis caused by intestinal perforations in the cecum versus colon, finding that cecum perforations lead to more severe outcomes due to higher bacterial burden and pathogenic microbial abundance.

Correlative single-cell hard X-ray tomography and X-ray fluorescence imaging

This paper develops a method to combine single-cell X-ray tomography and fluorescence imaging to study cellular structures and chemical element distributions.

Modification of social cheating facilitates the stabilization and chronic infection of polymorphic Pseudomonas aeruginosa population

The paper shows that evolution in Pseudomonas aeruginosa populations selects for cheater mutants that modify social cooperation to stabilize chronic infections and reduce host immune response.

Prioritizing Annotated miRNAs: Only a Small Percentage are Candidates for Biological Regulation

The paper identifies that only 2% of annotated miRNAs are likely to function as robust gene regulators based on their abundance, DROSHA dependence, and association with AGO proteins.

Is Tau the Initial Pathology in Dopaminergic Nigrostriatal Degeneration? Studies in Parkinsonism and Parkinson ' Disease

This study investigates whether tau pathology precedes dopaminergic neurodegeneration in Parkinsonism by comparing groups with and without synucleinopathy.

Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome

This study shows that metabolic rescue with nicotinamide riboside improves mitochondrial encephalo-cardiomyopathy in mouse and human iPSC models of Leigh syndrome.

Metabolic Derangement in Polycystic Kidney Disease Mouse Models Is Ameliorated by Mitochondrial-Targeted Antioxidants

This study shows mitochondrial-targeted antioxidants reduce oxidative stress and metabolic issues in PKD mouse models, improving disease progression and restoring metabolic pathways.

A highly conserved lipase deacylates oxidized phospholipids and ameliorates acute lung injury

This study identifies AOAH as a lipase that deacylates oxidized phospholipids, reducing inflammation and acute lung injury in vivo.

Dynamics of glioma-associated microglia and macrophages reveals their divergent roles in the immune response of brain

The paper uses single-cell sequencing to analyze glioma-associated microglia and macrophages, revealing their distinct roles in tumor progression and clinical outcomes.

The brown algae Saccharina japonica and Sargassum horneri exhibit species-specific responses to synergistic stress of ocean acidification and eutrophication

This study examines how Saccharina japonica and Sargassum horneri respond to ocean acidification and eutrophication, finding that S. horneri has competitive advantages under combined stress.

Genetic determinants of COVID-19 drug efficacy revealed by genome-wide CRISPR screens

This study identifies genetic determinants of COVID-19 drug efficacy using genome-wide CRISPR screens, revealing genes involved in drug metabolism and immunosuppressive effects.

A quasi-paired cohort strategy reveals the impaired detoxifying function of microbes in the gut of autistic children

This study identifies impaired microbial detoxification in autistic children using a quasi-paired cohort strategy, linking it to mitochondrial damage and potential therapeutic strategies.

Pod and seed trait QTL identification to assist breeding for peanut market preferences

This study identifies QTL for peanut seed and pod traits using a RIL population, finding major QTL with high PVE on specific linkage groups.

Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance

This study shows that PIF1 helicase deficiency in female mice on a Western diet leads to increased weight gain but not inflammation or reduced glucose clearance.

Gene-centric intra- and inter-clade recombination in a context of Escherichia coli subpopulations

The paper analyzes recombination patterns in Escherichia coli genomes to show extensive intra-clade recombination and reduced inter-clade recombination, establishing genetic barriers between subpopulations.