Author

I. Tabas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Yurdagul· 2 shared H. Shi· 2 shared X. Wang· 2 shared A. Sanyal· 1 shared A. Yamamoto· 1 shared B. Gerlach· 1 shared C. Xue· 1 shared C.-S. Lin· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPathology

A. Yurdagul

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Loss of TIM4-Dependent Efferocytosis in Kupffer CellsPromotes Liver Fibrosis in Nonalcoholic Steatohepatitis

H. Shi, X. Wang, B. Gerlach, A. Yurdagul, M. Moore, F. Mirshahi, L. Ronzoni, A. Sanyal, L. Valenti, C.-S. Lin, I. Tabas

This study shows that loss of TIM4 in Kupffer cells impairs efferocytosis of apoptotic hepatocytes in NASH, promoting liver fibrosis, and that restoring TIM4 reduces fibrosis.

bioRxiv · Jan 30, 2024 · PreprintPathology

Hepatocyte-Targeted siTAZ Therapy Lowers Liver Fibrosis in NASH Diet-Fed Chimeric Mice with Hepatocyte-Humanized Livers

X. Wang, M. P. Moore, H. Shi, Y. Miyata, S. K. Donnelly, D. R. Radiloff, I. Tabas

bioRxiv · Oct 27, 2023Pharmacology & Toxicology

Efferocytosis-Induced Lactate Enables the Proliferation of Pro-Resolving Macrophages to Mediate Tissue Repair

D. Ngai, M. Schilperoort, I. Tabas

This study shows that efferocytosis-induced lactate production stabilizes Myc protein, enabling macrophage proliferation and tissue repair.

bioRxiv · Mar 10, 2023Immunology

A Genome-wide CRISPR Screen Identifies WDFY3 as a Novel Regulator of Macrophage Efferocytosis

J. Shi, X. Wu, Z. Wang, F. Li, Y. Meng, R. M. Moore, J. Cui, C. Xue, K. R. Croce, A. Yurdagul, J. G. Doench, W. Li, K. S. Zarbalis, I. Tabas, A. Yamamoto, H. Zhang

This study identifies WDFY3 as a novel regulator of macrophage efferocytosis through a genome-wide CRISPR screen, revealing its role in actin depolymerization and lysosomal acidification.

bioRxiv · Jan 21, 2022Cell Biology