Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction
X. Gao, W. Guo, P. Liu, M. Yuwen, H. Ren, S. Hu, Z. Liu, R. Tan, K. Liu, Z. Yang, J. Ba, X. Bai, S. Shama, C. Tang, K. Miao, , J. Kang
This study shows capsaicin directly binds KEAP1 and allosterically activates NRF2, reducing ethanol-induced gastric oxidative damage and suggesting its potential as a novel NRF2 agonist for oxidative stress-related diseases.
bioRxiv · Jan 6, 2024Cell Biology