Author

A. Groth

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:chromatin & epigenetic regulation· 5 Organism:human· 4 Assay:ChIP-seq· 3 Research Focus:cell type annotation· 2 Assay:cryo-EM· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Biran· 3 shared F. Mattiroli· 2 shared G. Ricci· 2 shared A. E. E. Verkennis· 1 shared A. van Oudenaarden· 1 shared A. Wenger· 1 shared Alicia A. SorgeniD· 1 shared Amy T. BushiD· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCell Biology

A. Biran

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The impact of transplant location on the gut microbiome and resistome in patients undergoing hematopoietic stem cell transplantation at home versus in the hospital

Tessa M. Andermann, Ke Zeng, Sayal Guirales-Medrano, A. Groth, B.C. Ramachandran, S. Sun, Alicia A. Sorgen, L. Hill, Amy T. Bush, H. Liu, C. Jones, Jeffrey M. Roach, Brian P. Conlon, G. Rao, Nelson Jen An Chao, , Anthony Derek Sung

This study compares the gut microbiome and resistome of patients undergoing home versus hospital hematopoietic stem cell transplantation, finding no significant differences but noting confounding factors in secondary analyses.

bioRxiv · Nov 19, 2024 · PreprintMicrobiology

CODANIN-1 sequesters ASF1 by using a histone H3 mimic helix to regulate the histone supply

T.-K. Jeong, R. C. M. Frater, J. Yoon, A. Groth, J.-J. Song

This study determines the structure of the CODANIN-1_ASF1 complex, revealing how CODANIN-1 inhibits ASF1-mediated histone supply by sequestering ASF1 in the cytoplasm.

bioRxiv · Jul 10, 2024Biophysics

Acute multi-level response to defective de novo chromatin assembly in S-phase

J. Dreyer, G. Ricci, J. van den Berg, V. Bhardwaj, J. Funk, C. Armstrong, V. van Batenburg, C. Sine, M. A. Vaninsberghe, R. Marsman, I. K. Mandemaker, S. di Sanzo, J. Costantini, S. Manzo, A. Biran, , F. Mattiroli

This study investigates the acute effects of CAF-1 loss on chromatin assembly during S-phase, revealing multi-level responses including replication slowdown and histone modification changes.

bioRxiv · Mar 22, 2024Cell Biology

Repair of DNA double-strand breaks leaves heritable impairment to genome function

S. C. Bantele, I. Mordini, A. Biran, N. Alcaraz, A. Wenger, N. Krietenstein, A. Groth, J. Lukas

This study shows that DNA double-strand breaks cause lasting chromatin changes that are heritable and impair gene function beyond DNA repair.

bioRxiv · Aug 29, 2023 · PreprintCell Biology

CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands

C. Rouillon, B. V. Eckhardt, L. Kollenstart, F. Gruss, A. E. E. Verkennis, I. Rondeel, P. H. L. Krijger, G. Ricci, A. Biran, T. van Laar, C. M. Delvaux de Fenffe, G. Luppens, P. Albanese, R. A. Scheltema, W. de Laat, , F. Mattiroli

This study shows CAF-1 deposits histones on both DNA strands during replication but uses different mechanisms on leading and lagging strands.

bioRxiv · Oct 14, 2022Biochemistry

NASP maintains histone H3-H4 homeostasis through two distinct H3 binding modes

H. Bao, M. Carraro, V. Flury, Y. Liu, M. Luo, L. Chen, A. Groth, H. Huang

This study identifies two distinct H3 binding modes of NASP and shows how they cooperate to maintain histone H3-H4 homeostasis.

bioRxiv · Nov 2, 2021Biochemistry