Author

J. Gaedcke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 5 Research Focus:differential expression· 5 Organism:human· 5 Approach:statistical model· 5 Research Focus:cell type annotation· 3 Assay:metabolomics· 3 Research Focus:gene regulatory network inference· 2 Approach:experimental assay· 1

Frequent Co-Authors

A. Azizian· 3 shared H. Cawley· 3 shared H. Liu· 3 shared N. Hanna· 3 shared P. Moreno· 3 shared S. Ambs· 3 shared S. P. Hussain· 3 shared S. Yang· 3 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

A. Azizian

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5 papers

Recent·Most cited

LMO3 is a suppressor of the basal-like/squamous PDAC subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism

Y. Ohara, A. J. Craig, H. Liu, S. Yang, P. Moreno, T. H. Dorsey, H. Cawley, A. Azizian, J. Gaedcke, M. Ghadimi, N. Hanna, S. Ambs, S. P. Hussain

This study identifies LMO3 as a suppressor of the aggressive basal-like/squamous PDAC subtype, showing it reduces disease aggressiveness through modulation of glycerol 3-phosphate metabolism.

Carcinogenesis · Feb 15, 2024Peer-reviewedCancer Biology

ELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer

Y. Ohara, A. J. Craig, H. Liu, S. Yang, P. Moreno, T. H. Dorsey, H. Cawley, A. Azizian, J. Gaedcke, M. Ghadimi, N. Hanna, S. Ambs, S. P. Hussain

This study identifies ELAPOR1 as a tumor suppressor in pancreatic cancer, showing its association with reduced disease aggressiveness and a metabolic signature of the classical/progenitor subtype.

bioRxiv · Sep 23, 2023Cancer Biology

SERPINB3 induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer

Y. Ohara, W. Tang, H. Liu, S. Yang, T. H. Dorsey, H. Cawley, P. Moreno, A. Azizian, J. Gaedcke, B. M. Ghadimi, N. Hanna, S. Ambs, S. P. Hussain

This study identifies SERPINB3 as a marker for the basal-like/squamous subtype of pancreatic cancer, showing it promotes invasion, metastasis, and metabolic reprogramming.

bioRxiv · Mar 29, 2023Cancer Biology

Cancer-type specific aneuploidies hard-wire chromosome-wide gene expression patterns of their tissue of origin

N. Auslander, K. Heselmeyer-Haddad, S. Patkar, D. Hirsch, J. Camps, M. Brown, D. Bronder, W.-D. Chen, R. Lokanga, D. Wangsa, D. Wangsa, Y. Hu, A. Lischka, R. Braun, G. Emons, , t. ried

The paper shows cancer-type specific aneuploidies correlate with normal tissue gene expression patterns, suggesting they hard-wire chromosome-wide expression levels to support tumorigenesis.

bioRxiv · Mar 1, 2019Cancer Biology

Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery

Y. Hu, J. Gaedcke, G. Emons, T. Beissbarth, M. Grade, P. Jo, M. Yeager, S. Chanock, H. Wolff, J. Camps, M. B. Ghadimi, T. Ried

This study identifies three colorectal cancer risk loci associated with poor prognosis in rectal cancer patients and links some SNPs to chemoradiotherapy resistance.

bioRxiv · Jun 30, 2017Cancer Biology