J. J. Kelly

This study uses pH-sensitive peptides to deliver MHC-binding antigens to cancer cells, enhancing T cell activation for immunotherapy.

This study investigates how post-translational modifications affect MHC peptide binding and TCR engagement, revealing their impact on antigen presentation and potential implications for autoimmune diseases and tumor neoantigens.

The paper measures antibiotic accumulation in phagosomes of live macrophages infected with Staphylococcus aureus to assess permeability differences between extracellular and intracellular environments.

The paper evaluates synthetic stem peptide analogs to assess their impact on sortase A activity in S. aureus, showing broad tolerability of substrate variations.

This paper develops an MRI reporter system using oatp1b3 to track metastasis in live mice with high resolution and sensitivity.

The paper analyzes genetic and transcriptional profiles of glioblastomas, organoids, and cell lines to show variable retention of tumor heterogeneity in organoids and uniformity in cell lines.

The paper captures structural snapshots of actin and tubulin folding within the TRiC chaperonin using cryo-EM, revealing how substrates interact with the chamber during folding.

This study uses a novel mouse model to show that spontaneous metastases in synchronous bilateral breast cancer originate from both primary tumors, revealing high cross-seeding of metastatic cells.

The paper develops a CRISPR/Cas9 HITI system for precise, safe harbor locus integration of multi-modality reporter genes for cell tracking.

This study demonstrates that self-homing circulating tumor cells can target and treat metastatic breast cancer using gene therapy and bioluminescence imaging.