J. J. Krolewski

This study shows that stromal compartments in a mouse model of BPH are resistant to castration-induced regression, suggesting the need for additional therapies.

This study shows TNF signaling is required for castration-induced vascular damage in prostate cancer, which contributes to tumor regression.

This study shows that glucocorticoid signaling delays castration-induced regression in murine prostate cancer models by maintaining tumor proliferation through GR activation, which can be blocked by the GR antagonist relacorilant.