M. Mammadli

Wnt/β-catenin regulates alloreactive T cells for the treatment of hematological malignancies

This study shows that β-catenin regulates donor T cells in allo-HSCT, reducing GVHD while preserving GVL effects through altered cytokine production and cytotoxicity.

TCF-1 in CD4 T cells regulates GVHD severity and persistence

This study shows that loss of TCF-1 in mature CD4 T cells reduces GVHD severity and persistence by impairing T cell function and increasing exhaustion.

TCF-7 is dispensable for the anti-tumor response but required for the persistent function of mature CD8 T cells

This study shows TCF-7 is not needed for anti-tumor response but is required for long-term function of mature CD8 T cells.

Loss of TCF-1 regulates the production of noncanonical Tregs in a prion-like manner

The paper shows that loss of TCF-1 expands noncanonical Tregs and that TCF-1-deficient T cells promote their production from wild-type cells.

Inhibition of ITK differentiates GVT and GVHD in allo-HSCT

This paper shows that inhibiting ITK in donor T cells reduces GVHD while preserving GVT effects in allo-HSCT using murine models and a novel peptide inhibitor.

CrkL is required for donor T cell migration to GvHD Target organs

This study identifies CrkL as essential for donor T cell migration to GvHD target organs, showing that CrkL-deficient T cells cannot migrate into inflamed tissues but can still eliminate hematopoietic tumors.