J. L. Ross

Protein condensate fusion mapping using Hippopede curve

The paper uses hippopede curves to quantify biophysical properties of protein condensates during fusion.

Lateral and longitudinal compaction of PRC1 overlap zones drive stabilization of interzonal microtubules

This study shows that lateral and longitudinal compaction of PRC1 overlap zones is required for stabilizing midzone microtubules during telophase.

Spatially controlled microtubule nucleation and organization from crosslinker MAP65 condensates

This study shows that MAP65-1 forms phase-separated condensates that nucleate microtubule bundles in plant cells, suggesting a universal mechanism for microtubule organization.

The novel compensatory reciprocal interplay between neutrophils and monocytes drives cancer progression

This paper shows that eliminating monocyte chemoattraction increases neutrophil infiltration in glioblastoma, promoting tumor aggression, and that targeting both monocytes and neutrophils improves survival in mouse models.

A paracrine circuit of IL-1b/IL-1R1 between myeloid and tumor cells drives glioblastoma progression

The paper identifies a paracrine IL-1β/IL-1R1 circuit between myeloid and tumor cells that drives glioblastoma progression and shows that antagonizing this circuit reduces tumor growth and extends survival.

Active Cytoskeletal Composites Display Emergent Tunable Contractility and Restructuring

This study combines experiments and modeling to show how actin, tubulin, and myosin composites exhibit tunable contractility and restructuring through their connectivity and motor density.

Myosin-driven actin-microtubule networks exhibit self-organized contractile dynamics

This study investigates myosin-driven actin-microtubule networks and finds they exhibit self-organized contractile dynamics distinct from actin-only networks.

Molecular Investigations into the Unfoldase Action of Severing Enzymes on Microtubules

The paper uses molecular simulations to test a model of microtubule severing by unfolding enzymes, finding that enzyme concentration and placement affect cooperative removal of protofilament fragments.

Self-Organization of Spindle-Like Microtubule Structures

This study investigates microtubule self-organization using crosslinkers alone, revealing that antiparallel crosslinker concentration can form spindle-like structures without motor activity.

Varying crosslinking motifs drive the mesoscale mechanics of actin-microtubule composites

This study investigates how different crosslinking motifs affect the mechanical properties of actin-microtubule composites, revealing scale-dependent elastic and viscous behaviors.

Co-entangled actin-microtubule composites exhibit tunable stiffening and power-law stress relaxation

This study investigates the mechanical properties of actin-microtubule composites, finding that microtubules significantly increase resistive force and induce power-law stress relaxation.

Sorting of molecular shuttles by designing electrical and mechanical properties of microtubules

The paper designs microtubules with controlled electrical and mechanical properties to enable directional sorting in microfluidic devices, achieving 80% efficiency in separating stiff from negatively-charged microtubules.