D. Ng

Prenylation controls proliferation in human pluripotent stem cell-derived cardiomyocytes

This study identifies prenylation as a regulator of cardiomyocyte proliferation through multiple targets, suggesting its potential for cardiac regeneration.

Rapid differentiation of estrogen receptor status in patient biopsy breast cancer aspirates with an optical nanosensor

This paper develops an optical nanosensor using carbon nanotubes to rapidly detect estrogen receptor status in breast cancer biopsies with high accuracy.

Investigating the importance of surface exposed loops in the gonococcal HpuB transporter for hemoglobin binding and utilization

This study investigates the role of surface loops in the gonococcal HpuB transporter in hemoglobin binding and iron utilization, showing loop 7 is critical for function.

Structural adaptability and surface activity oftardigrade-inspired peptides

This paper studies model peptides derived from tardigrade proteins to mimic their structural behavior under desiccation, finding they adopt helical structures similar to full proteins.

Prevalence of Slam-dependent hemophores in Gram-negative bacteria

The paper identifies HphAs as a new class of hemophores in Gram-negative bacteria, showing their structural similarity to hemophilin1 and dependence on Slam for secretion.

SLC3A2 N-glycosylation and alternate evolutionary trajectories for amino acid metabolism

This study investigates how N-glycosylation sites on SLC3A2 evolve and regulate amino acid transport and redox balance, revealing their role in cellular trafficking and bird evolution.

A Novel Ex Vivo Peritoneal Model to Investigate Mechanisms of Peritoneal Metastasis in Gastric Adenocarcinoma

This paper develops an ex vivo human peritoneal explant model to study gastric adenocarcinoma metastasis and shows it responds to genetic manipulations affecting implantation.

Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasis

This study shows that combining MPLA and IFNγ reprograms macrophages to kill cancer cells and reduce metastasis in breast and ovarian cancer models.

Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis

This study shows that Cep55 regulates PI3K/Akt signaling, essential for neocortical development and ciliogenesis, using mouse models and human organoids.

Canine distemper in Nepal’s Annapurna Conservation Area - The implications of dog husbandry and human behaviour for wildlife disease

The paper assesses dog husbandry practices and CDV prevalence in Nepal’s Annapurna Conservation Area, finding high seroprevalence and suggesting potential CDV transmission to wild carnivores.

Endogenous BioID elucidates TCF7L1 interactome modulation upon GSK-3 inhibition in mouse ESCs

The paper uses BioID to study TCF7L1 interactome changes in mouse ESCs with GSK-3 inhibition, identifying new interactors and showing increased detection with reduced BirA*-TCF7L1 levels.