R. Sheldon

The Caenorhabditis elegans bacterial microbiome influences microsporidia infection through nutrient limitation and inhibiting parasite invasion

The paper shows that certain bacteria reduce microsporidia infection in C. elegans by altering host metabolism and producing inhibitory compounds.

Metabolomics and 13C Labelled Glucose Tracing to Identify Carbon Incorporation into Aberrant Cell Membrane Glycans in Cancer

This study uses metabolomics and 13C tracing to examine glucose allocation to membrane glycans in pancreatic cancer cell lines, revealing differences in glycan synthesis and metabolic pathways.

ASCT2 is the primary serine transporter in cancer cells

This study identifies ASCT2 as the primary serine transporter in cancer cells and shows its role in purine biosynthesis and therapeutic targeting.

Acod1 Expression in Cancer Cells Promotes Immune Evasion through the Generation of Inhibitory Peptides

This study shows that Acod1 in cancer cells promotes immune evasion by releasing inhibitory peptides, not ITA, and that reducing Acod1 can make tumors responsive to PD-1 therapy.

Comparison of concentrations of lead (Pb) in meat from wild-shot common pheasants killed using shotgun pellets principally composed of lead, iron (Fe), bismuth (Bi) and zinc (Zn)

This study compares lead concentrations in meat from pheasants shot with lead or iron pellets, finding significantly higher lead levels in those shot with lead.

An acute microglial metabolic response controls metabolism and improves memory

The paper identifies an acute microglial metabolic response to high-fat diet that improves metabolism and memory by converting harmful fatty acids into beneficial metabolites.

Reprogramming of Iron Metabolism Confers Ferroptosis Resistance in ECM-Detached Cells

This study shows ECM-detached cancer cells resist ferroptosis due to reduced free iron levels from altered iron metabolism, suggesting potential limitations for ferroptosis-based therapies.

Ketolysis is a metabolic driver of CD8+ T cell effector function through histone acetylation

This study identifies ketone bodies as essential for CD8+ T cell metabolism and effector function through histone acetylation regulation.