J. Merrin

Size-Dependent Mechanoadaptation Enables Migration with Oversized Parasitic Cargo

The paper investigates how cells adapt to transport oversized parasitic cargo by reprogramming mechanical forces and subcellular architecture during migration.

Adaptive Pathfinding by Nucleokinesis during Amoeboid Migration

This study shows that amoeboid cells use nucleokinesis, a process of nuclear repositioning, to adaptively navigate heterogeneous microenvironments by reorienting between competing signals.

Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts

The paper shows cortical Actin flows, driven by Myosin-2 depletion, mediate E-cadherin redistribution and cell contact formation.

Synchronization in collectively moving inanimate and living active matter

The paper identifies actin wave synchronization as a mechanism for collective cell motion in confined environments and demonstrates this through mechanical models.

Sinking the way: a dual role for CCR7 in collective leukocyte migration

This study shows CCR7 has a dual role in leukocyte migration by both sensing and consuming its ligand to generate and modulate chemotactic gradients.

Mechanosensitivity of amoeboid cells crawling in 3D

This study shows how amoeboid cells use WASp-driven actin spikes to push against mechanical loads in 3D environments, enabling efficient migration through dense tissues.

Adhesion-free cell migration by topography-based force transduction

This study shows leukocytes can migrate without adhesion by using substrate topography to transduce force from actin retrograde flow.

Microtubules control cellular shape and coherence in amoeboid migrating cells

This study shows that microtubules regulate protrusion retraction in migrating cells by controlling myosin II contractility through Lfc, maintaining cell shape and coherence.