Author

H. Granzier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

P. S. Rabinovitch· 2 shared Y. A. Chiao· 2 shared A. D. Chakraborty· 1 shared C. F. Lee· 1 shared C. Fiorillo· 1 shared C. U. Braz· 1 shared C. Wallgren-Pettersson· 1 shared D. Duan· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersPhysiology

P. S. Rabinovitch

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Author profile →

4 papers

Recent·Most cited

Late-life Rapamycin Treatment Enhances Cardiomyocyte Relaxation Kinetics and Reduces Myocardial Stiffness

A. D. Chakraborty, K. Kooiker, K. A. Kobak, Y. Cheng, C. F. Lee, M. Razumova, H. Granzier, M. Regnier, P. S. Rabinovitch, F. Moussavi-Harami, Y. A. Chiao

This study shows that late-life rapamycin treatment improves cardiomyocyte relaxation and reduces myocardial stiffness in aged mice, reversing diastolic dysfunction.

bioRxiv · Jun 12, 2023 · PreprintPhysiology

Disruption of the nuclear localization signal in RBM20 is causative in dilated cardiomyopathy

Y. Zhang, Z. R. Gregorich, Y. Wang, C. U. Braz, J. Zhang, Y. Liu, P. Liu, N. Aori, T. A. Hacker, H. Granzier, W. Guo

This study identifies disruption of the nuclear localization signal in RBM20 as a causative mechanism in dilated cardiomyopathy through impaired nucleocytoplasmic transport.

bioRxiv · Dec 8, 2022Cell Biology

Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

Y. A. Chiao, H. Zhang, M. Sweetwyne, J. Whitson, Y. S. Ting, N. Basisty, L. Pino, E. Quarles, N.-H. Nguyen, M. Campbell, T. Zhang, M. J. Gaffrey, G. Merrihew, L. Wang, Y. Yue, , P. S. Rabinovitch

This study shows that treating old mice with SS-31 improves cardiac diastolic function by reducing mitochondrial oxidative stress and restoring redox balance.

bioRxiv · Jan 2, 2020Physiology

Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy

J. A. Ross, Y. Levy, M. Ripolone, J. S. Kolb, M. Turmaine, M. Holt, M. Moggio, C. Fiorillo, J. Lindqvist, N. Figeac, P. Zammit, H. Jungbluth, J. Vissing, N. Witting, H. Granzier, , J. Ochala

This study identifies nuclear defects in nemaline myopathy caused by impaired contractility and cytoskeletal organisation in muscle fibres.

bioRxiv · Jan 28, 2019Cell Biology