P. Bose

Spatially resolved single-cell analysis uncovers protein kinase C-& expressing microglia with anti-tumor activity in glioblastoma

This study identifies PKCδ-expressing microglia with anti-tumor activity in GBM using spatial transcriptomics and confirms their presence in human samples.

Revealing Molecular Mechanisms of Early-Onset Tongue Cancer by Spatial Transcriptomics

This study identifies distinct spatial transcriptomic features and molecular mechanisms in early-onset tongue cancer compared to older patients.

Single cell spatial analysis identifies regulators of brain tumor initiating cells

The paper identifies biglycan as a regulator of brain tumor initiating cells through spatial transcriptomics and single-cell ATAC-seq, showing its role in Wnt/β-catenin pathway activation and tumor growth.

Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response

This study uses spatial transcriptomics to analyze tumor core and edge regions in OSCC, revealing distinct transcriptional profiles and their clinical implications across multiple cancers.

Ganglioside enriched phospholipid vesicles induce cooperative Aβ oligomerization and membrane disruption

This study shows that GM1-enriched liposomes promote toxic Aβ oligomerization and membrane disruption through cooperative processes.

Oral Glucosamine Ameliorates Aggravated Neurological Phenotype in Mucopolysaccharidosis III Type C Mouse Model Expressing Misfolded HGSNAT Variant

This study shows oral glucosamine improves neurological symptoms in a mouse model with misfolded HGSNAT due to a Pro304Leu mutation.

Clinicopathologic Correlates and Natural History of Atypical Chronic Myeloid Leukemia

This study examines clinicopathologic features and treatment outcomes in 65 patients with atypical chronic myeloid leukemia, identifying key mutations and predictors of survival.

Molecular Determinants of Prognosis and Evolution in Diffuse-Lower Grade Astrocytomas

This study identifies PDGF pathway activation as a key driver of rapid progression in IDH wild-type low-grade astrocytomas compared to mutant tumors.

ATM-deficient lung, prostate and pancreatic cancer cells are acutely sensitive to the combination of olaparib and the ATR inhibitor AZD6738

This study shows that ATM-deficient cancer cells are more sensitive to the combination of olaparib and AZD6738, leading to cell death.

ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup