S. Boyd

Multi-Omics after O-GlcNAc Alteration Identifies Cellular Processes Working Synergistically to Promote Aneuploidy

The paper uses multi-omics analysis to show OGT regulates aneuploidy by fine-tuning multiple cellular pathways through O-GlcNAcylation.

Sugar distributions on gangliosides guide the formation and stability of amyloid-β oligomers

This study shows that sugar distributions on gangliosides modulate Aβ oligomerization and stability.

Meta-analysis using new methods for three-stressor combinations reveal substantial higher-order interactions and emergent properties

The paper reanalyzes 151 ecological three-stressor interactions using new methods, finding 89% showed new interactions and substantial emergent properties.

An ex vivo human bone marrow milieu identifies CDH2 as a driver of niche-mediated treatment resistance in leukaemia

This study identifies CDH2 as a driver of niche-mediated treatment resistance in leukemia and shows that ADH-1 can effectively target this resistance in preclinical models.

Adult fibroblasts retain organ-specific transcriptomic identity

This study shows fibroblasts retain organ-specific transcriptomic identity across development, culture, and transplants, with implications for targeted fibrotic disease treatment.

Safety, immunogenicity and protection provided by unadjuvanted and adjuvanted formulations of recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in non-human primates

This study evaluates the safety and immunogenicity of a plant-derived VLP vaccine against SARS-CoV-2 in non-human primates, finding that AS03 adjuvanted vaccine provides better protection and immune response.

Structural and molecular determinants of CCS-mediated copper activation of MEK1/2

The paper reports the X-ray structure of Cu-MEK1, revealing Cu coordination and CCS-mediated Cu transfer, and identifies molecular mechanisms for Cu-stimulated MEK1 kinase activity.