L. Xia

Single-Cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape

This study shows that an ENL mutation disrupts kidney development by altering gene regulation, leading to developmental defects and early death in mice, and suggests potential therapeutic strategies.

Potential clinical value and influence of conductivity in conductive cardiac patches for reducing post-MI arrythmia risks

This study evaluates the clinical value of conductive cardiac patches by testing different conductivities and shows that higher conductivity reduces arrhythmia risks in post-MI hearts.

Artificial neural networks for model identification and parameter estimation in computational cognitive models

This paper uses artificial neural networks to estimate parameters and identify cognitive models without likelihood computation, demonstrating effectiveness for models with inter-trial dependencies.

MIIP downregulation promotes colorectal cancer progression via inducing adjacent adipocytes browning

This study shows MIIP downregulation in colorectal cancer promotes tumor progression by inducing adjacent adipocytes to brown, releasing free fatty acids that fuel cancer growth.

Smart squirrels use a mortise-tenon structure to fix nuts on understory twigs

The paper describes how two species of flying squirrels in Hainan Island use a mortise-tenon structure to securely cache nuts on twigs to deter predation and ensure food supply.

Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against Omicron

This study identifies antibodies effective against Omicron by analyzing epitope changes and binding patterns, showing their ability to neutralize the virus through a conserved mechanism.

CXCL8/CXCR2 signaling mediates bone marrow fibrosis and represents a therapeutic target in myelofibrosis

This study identifies CXCL8/CXCR2 signaling as a driver of bone marrow fibrosis in myelofibrosis and shows its therapeutic potential through genetic and pharmacologic inhibition.

Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy

This study shows that reducing dermal white adipose tissue (dWAT) worsens EGFR inhibitor-induced skin rash in mice, and activating PPARγ with rosiglitazone improves skin function without affecting antitumor effects.

CaPti1/CaERF4 module positively regulates pepper resistance to bacterial wilt disease through coupling enhanced immunity and dehydration tolerance

This study identifies the CaPti1-CaERF4 module as a regulator that couples immunity and dehydration tolerance in pepper plants to enhance resistance to bacterial wilt disease.

Biosynthetic gene cluster profiling predicts the positive association between antagonism and phylogeny in Bacillus

The paper investigates the relationship between antagonism and phylogeny in Bacillus by analyzing biosynthetic gene clusters (BGCs) and finds a positive correlation between BGC distance and phylogenetic distance.

Genome-wide Association Study of Pancreatic Fat: The Multiethnic Cohort Adiposity Phenotype Study

This study identifies two genetic variants associated with pancreatic fat content and suggests a potential link between pancreatic fat and type 2 diabetes.

A potent neutralizing human antibody reveals the N-terminal domain of the Spike protein of SARS-CoV-2 as a site of vulnerability

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

Transgenerational inheritance of abnormal spermatogenesis with Igf2/H19 epigenetic alteration in CD1 mouse induced by in utero arsenic exposure

This study shows that prenatal arsenic exposure in mice leads to transgenerational impairments in spermatogenesis, associated with epigenetic changes in Igf2 and H19.

Structural basis for the recognition of the 2019-nCoV by human ACE2

This study determines the cryo-EM structure of human ACE2 bound to the RBD of 2019-nCoV, revealing key interactions and differences compared to SARS-CoV.

Structure of dimeric full-length human ACE2 in complex with B0AT1

The paper presents the cryo-EM structure of human ACE2 in complex with B0AT1, revealing dimeric conformations and potential binding sites for SARS-CoV spike proteins.

Lipid-specific labeling of enveloped viruses with quantum dots for single-virus tracking

This paper develops a lipid-specific quantum dot labeling method to track enveloped viruses, showing it preserves virus integrity and enables efficient tracking of viral infection dynamics.

Global gene expression profile during low temperature in the brain of grass carp (Ctenopharyngodon idellus)

This study investigates the transcriptome changes in grass carp brains under low temperature, identifying key pathways and genes involved in cold acclimation.