X. Sheng

A Silicon Diode based Optoelectronic Interface for Bidirectional Neural Modulation

This paper demonstrates a silicon diode device that bidirectionally modulates neural activity in vitro and in vivo through photothermal and photovoltaic effects.

Battery-Free Optoelectronic Patch for Photodynamic and Light Therapies in Treating Bacteria-Infected Wounds

This paper introduces a battery-free optoelectronic patch for photodynamic and light therapies to treat bacterial infections, showing reduced bacterial load and enhanced tissue regeneration in animal models.

NeuroMotion: Open-source Simulator with Neuromechanical and Deep Network Models to Generate Surface EMG signals during Voluntary Movement

NeuroMotion generates synthetic EMG signals during voluntary movements by integrating musculoskeletal models, neural networks, and motor unit models, enabling analysis of neuromechanical interactions.

A pseudovirus-based method to dynamically mimic SARS-CoV-2-associated cell-to-cell fusion and transmission

This paper introduces a pseudovirus-based method to mimic SARS-CoV-2 cell-to-cell fusion and transmission, demonstrating its utility for screening inhibitors and studying variant fusogenic ability.

A Wireless Optoelectronic Probe Monitors Tissue Oxygenation in the Deep Brain

This paper introduces a wireless optoelectronic probe that continuously monitors brain tissue oxygenation in live animals, capturing hypoxia states and linking PbtO2 changes to neural activity.

The photosystem I supercomplex from a primordial green alga Ostreococcus tauri harbors three light-harvesting complex trimers

This paper reports the structure and function of the photosystem I supercomplex in Ostreococcus tauri, showing it assembles with light-harvesting complexes and exhibits reversible photoacclimation.

Accumulation of mitochondrial ROS drives reductive glutamine metabolism

This study shows mitochondrial ROS drives reductive glutamine metabolism by promoting reductive carboxylation, with ROS levels directly correlating with metabolic activity.

CRISPR/Cas9 mutants delineate roles of Populus FT and TFL1/CEN/BFT family members in growth, dormancy release and flowering

This study uses CRISPR/Cas9 to generate mutants in Populus FT and TFL1/CEN/BFT genes, revealing their roles in growth, dormancy release, and flowering.

Dissecting the genetic basis of the heterosis of Y900, an elite super-hybrid rice

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

Silicon Diode based Flexible and Bioresorbable Optoelectronic Interfaces for Selective Neural Excitation and Inhibition

This paper develops bioresorbable silicon diodes for non-genetic neural excitation and inhibition, showing they modulate intracellular calcium dynamics and function in vivo.

Sequential functional differentiation of luminal epithelial cells regulated by maternal and embryonic signaling in the mouse endometrium

The paper identifies maternal and embryonic signaling-driven differentiation of luminal epithelial cells in the mouse endometrium and shows conservation in humans.

miR-206 inhibits estrogen-induced proliferation and invasion of ER-α36 positive gastric cancer cells

This study shows miR-206 reduces estrogen-induced proliferation and invasion of ER-α36 positive gastric cancer cells by targeting CDK14.

Colocalized, Bidirectional Optogenetic Modulations in Freely Behaving Animals with a Wireless Dual-Color Optoelectronic Probe

This paper develops a wireless dual-color optogenetic probe to bidirectionally modulate neuronal activity in freely moving mice, revealing its impact on dopamine levels and behavior.

Genome-wide Association Study of Pancreatic Fat: The Multiethnic Cohort Adiposity Phenotype Study

This study identifies two genetic variants associated with pancreatic fat content and suggests a potential link between pancreatic fat and type 2 diabetes.

First demonstration of the FLASH effect with ultrahigh dose-rate high-energy X-rays

This paper demonstrates the first use of high-energy X-rays in FLASH radiotherapy, showing effective tumor control and tissue protection in mice.

Renal proximal tubule cell state and metabolism are coupled by nuclear receptors

The paper identifies proximal tubule cell state and metabolism as coupled by nuclear receptors in kidney disease using single-cell RNA-sequencing.

Circuit-free, optoelectronic sensing of electrodermal activities based on photon recycling of a micro-LED

This paper demonstrates an optoelectronic method to capture electrodermal activities using a micro-LED, showing improved performance over traditional electrical sensors.

Rapid adaptation of SARS-CoV-2 in BALB/c mice: Novel mouse model for vaccine efficacy

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

Ratio of the interferon-γ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

This study shows that overexpressing Cpt1a in renal tubular epithelial cells reduces fibrosis by restoring mitochondrial function and bioenergetics in CKD models and human patients.

A wireless, implantable optoelectrochemical probe for optogenetic stimulation and dopamine detection

This paper introduces a wireless, implantable optoelectrochemical probe for optogenetic stimulation and dopamine detection in freely behaving mice.

Rapidly cycling stem cells regenerate the intestine independent of Lgr5high cells

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.

Stromal ISLR promotes intestinal regeneration and cancer by suppressing epithelial Hippo signaling

This study identifies ISLR as a stromal factor that suppresses epithelial Hippo signaling to promote intestinal regeneration and cancer.

Deubiquitylation and stabilization of p21 by USP11 is critical for cell cycle progression and DNA damage responses

This study identifies USP11 as a deubiquitylase that stabilizes p21, affecting cell cycle progression and DNA damage responses.